牙龈卟啉单胞菌在消化系统肿瘤中的作用及机制研究  

The Role and Mechanism of Porphyromonas gingivalis in Digestive System Tumors

作　　者：兰子君 原翔 张灏 王立东[3] 刘雅莉[4] 詹启敏[5] 高社干 LAN Zi-jun;YUAN Xiang;ZHANG Hao;WANG Li-dong;LIU Ya-li;ZHANG Qi-min;GAO She-gan(Henan Key Laboratory of Cancer Epigenetics,Cancer Hospital,The First Affiliated Hospital,College of Clinical Medicine,Medical College of Henan University of Science and Technology,Luoyang 471003,China;Institute of Precision Cancer Medicine and Pathology,Jinan University Medical College,Guangzhou 510632,China;Henan Key Laboratory of Esophageal Cancer,the First Affiliated Hospital of Zhengzhou University,State Key Laboratory of Esophageal Cancer Prevention&Treatment,Zhengzhou 450052,China;Institute of Medical Information,Zhengzhou 450046 China;State Key Laboratory of Molecular Oncology,Cancer Institute and Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)

机构地区：[1]河南科技大学,医学院,临床医学院,第一附属医院,肿瘤医院,河南省肿瘤表观遗传重点实验室,河南洛阳471003 [2]暨南大学医学院,肿瘤精准医学与病理研究所,广东广州510632 [3]郑州大学第一附属医院河南省食管癌重点开放实验室,省部共建食管癌防治国家重点实验室,河南郑州450052 [4]河南省医学情报研究所,河南郑州450046 [5]中国医学科学院北京协和医学院肿瘤研究所,分子肿瘤学国家重点实验室,北京100021

出　　处：《食管疾病》2020年第1期18-25,共8页Journal of Esophageal Diseases

基　　金：国家自然科学基金(81972571)。

摘　　要：越来越多的证据表明牙周疾病是导致消化系统肿瘤的一个重要危险因素,而牙龈卟啉单胞菌(Pg)是引起牙周疾病及慢性牙周炎的关键病原体。大量研究表明,牙龈卟啉单胞菌除在口腔中具有局部作用外,还可能引发其他器官肿瘤,该细菌可能与胃和结肠的癌前病变、食管鳞状细胞癌、头颈部肿瘤和胰腺癌存在密切关系。本文重点总结了牙龈卟啉单胞菌和消化系统肿瘤之间的关系及相互作用机制的最新研究进展。There is increasing evidence that periodontal disease is an important risk factor for digestive system tumors.Porphyromonas gingivalisis a key pathogen causing periodontal disease and chronic periodontitis.Abundant studies have shown that Porphyromonas gingivalis has systemic carcinogenic effects in addition to its local role in the oral cavity:possibly the precancerous gastric and colon lesions,esophageal squamous cell carcinoma,head and neck tumors and pancreatic cancer are all involved in.This review highlights the latest research progress on the relationship and interaction mechanism between Porphyromonas gingivalis and digestive system tumors.

关 键 词：牙龈卟啉单胞菌 消化系统肿瘤 口腔鳞状细胞癌 食管鳞状细胞癌 致病机制 

分 类 号：R-735.1[医药卫生]