纤维蛋白原Bβ-455G/A基因多态性与小动脉闭塞性脑梗死  

The fibrinogen Bβ-455G/A gene polymorphism associated with small-artery-occlusion cerebral infarction

作　　者：李军廷 陈晓虹[1] Li Junting;Chen Xiaohong(Department of Neurology,the People′s Hospital of Liaoning Province,Shenyang 110016,China)

机构地区：[1]辽宁省人民医院神经内科,沈阳110016

出　　处：《中华神经科杂志》2020年第3期221-226,共6页Chinese Journal of Neurology

基　　金：辽宁省自然基金资助项目(20170540528);沈阳市科学技术计划项目(18-014-4-98)。

摘　　要：纤维蛋白原是一种具有止血凝血作用、参与血栓形成过程并参与介导炎性反应的糖蛋白。目前纤维蛋白原及纤维蛋白原Bβ-455G/A基因多态性与缺血性卒中之间的关系已受到人们的关注,但相关研究报道还不多见,尤其是与小动脉闭塞性脑梗死关系的研究鲜有报道,且结论不一。本文对近年来关于纤维蛋白原及纤维蛋白原Bβ-455G/A基因多态性与缺血性卒中,主要是与小动脉闭塞性脑梗死的相关性研究做一综述。Fibrinogen is a glycoprotein that has hemostatic and clotting effects and participates in the process of thrombosis,and also participates in the process of mediating inflammatory response.At present,the study on the relationship between fibrinogen,fibrinogen Bβ-455G/A gene polymorphism and ischemic stroke has attracted people′s attention,but there are few relevant reports,especially the study on the relationship between fibrinogen,fibrinogen Bβ-455G/A gene polymorphism and small-artery-occlusion cerebral infarction,and the conclusions are inconsistent.This paper reviews the recent studies on the correlation between fibrinogen,fibrinogen Bβ-455G/A gene polymorphism and ischemic stroke,mainly with small-artery-occlusion cerebral infarction.

关 键 词：纤维蛋白原 脑梗塞 小动脉 多态现象 遗传 

分 类 号：R74[医药卫生—神经病学与精神病学]