孟德尔随机化法在常见老年病病因探索中的应用进展  

Advances in the application of Mendelian randomization in investigating the etiologies of common diseases in the elderly

作　　者：张莹[1,2] 陈晨 杨睿悦 周起[1] 栗向辉 杨泽 孙亮[1] Zhang Ying;Chen Chen;Yang Ruiyue;Zhou Qi;Li Xianghui;Yang Ze;Sun Liang(The MOH Key Laboratory of Geriatrics,Beijing Hospital,National Center of Gerontology,Beijing 100730,China;Peking University Fifth School of Clinical Medicine,Beijing 100730,China)

机构地区：[1]北京医院,国家老年医学中心,卫健委老年医学重点实验室,100730 [2]北京大学第五临床医学院,100730

出　　处：《中华老年医学杂志》2020年第3期352-356,共5页Chinese Journal of Geriatrics

基　　金：国家自然科学基金(81571385);北京医院科技新星项目(BJ-2018-139);北京医院博士启动基金(bj-2018-024)。

摘　　要：孟德尔随机化法是在横断面研究数据中通过引入基因型作为暴露因素的工具变量而进行混杂校正的遗传流行病学方法,对无法测量、未知的混杂因素的校正有独特的优势。近年来该方法在老年常见病的病因研究中得到广泛应用且进展较快。本文就此方法原理及其在心血管疾病、2型糖尿病、骨质疏松症、阿尔茨海默病、恶性肿瘤等老年常见病中的应用进展进行综述。Mendelian randomization is a genetic epidemiological method for confounding adjustment of cross-sectional data by introducing genotypes as instrumental variables of exposure factors and possesses unique advantages for the adjustment of unmeasured and unknown confounding factors.In recent years,Mendelian randomization has been widely used and achieved rapid progress in the etiology research of common diseases in the elderly.This article reviews this method and its application in these diseases,including cardiovascular disease,type 2 diabetes mellitus,osteoporosis,Alzheimer's disease and malignant tumor.

关 键 词：孟德尔随机化法 混杂因素(流行病学) 病因研究 

分 类 号：R[医药卫生]