基于子午流注理论探讨化瘀通便汤治疗慢传输型便秘的临床研究  

Clinical Research of Huayu Tongbian Decoction in Treatment of Slow Transit Constipation Based on Theory of Midnight-noon Ebb-flow

作　　者：陈萌[1] 于永铎[2] 隋楠[1] 张斯瑶[1] CHEN Meng;YU Yongduo;SUI Nan;ZHANG Siyao(The Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110003,Liaoning,China;The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China)

机构地区：[1]辽宁中医药大学附属第三医院,辽宁沈阳110003 [2]辽宁中医药大学附属医院,辽宁沈阳110847

出　　处：《辽宁中医杂志》2020年第2期143-144,共2页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金青年基金项目(81804094);辽宁省科技厅项目;辽宁省便秘病重点实验室。

摘　　要：目的基于子午流注理论探讨化瘀通便汤治疗慢传输型便秘的临床疗效。方法选取辽宁中医药大学附属第三医院的慢传输型便秘患者82例,随机分为治疗组41例,对照组41例(脱落1例)。治疗组基于子午流注理论在大肠经最活跃时间给与化瘀通便汤口服治疗,对照组常规时间给药。观察患者治疗前后排便频率、粪便性状、使用泻剂、腹胀和每次排便时间并记录积分。结果治疗组和对照组治疗前后自身总积分比较有统计学差异(P <0. 01),提示两组治疗均有效,治疗后两组总积分比较无统计学差异(P> 0. 05),但治疗组总积分降低幅度比对照组大。治疗组总有效率为82. 9%(34/41),对照组总有效率为80. 0%(32/40),提示两组治疗均有效,两组临床疗效无统计学差异(P> 0. 05),但治疗组总有效率高于对照组2. 9%。结论治疗组和对照组虽然积分和总有效率比较无统计学差异,但在积分趋势和总有效率数值大小提示,基于子午流注理论在大肠经最活跃时间给与中药口服效果优于常规时间口服,为临床用药提供参考。随着临床观察样本量的增大,期待出现统计学差异。Objective To explore the clinical effect of Huayu Tongbian Decoction on slow transit constipation(STC)based on the theory of midnight-noon ebb-flow theory.Methods A total of 82 STC patients who were from The Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine were randomly divided into treatment group(41 cases)and control group(41 cases,1 case of abscission).The treatment group was given orally Huayu Tongbian Decoction at the most active time of the intestinal meridian based on midnight-noon ebb-flow theory,while the control group was given orally the routine treatment.We observed defecation frequency,feces traits,the use of laxative,abdominal distension and integral time of defecation before and after treatment.Results There was significant difference in the total score between the treatment group and the control group before and after treatmen(P<0.01),suggesting that both groups were effective.There was no significant difference in the total score between the two groups after treatment(P>0.05),but the decrease of the total score in the treatment group was greater than that in the control group.The total effective rate was 82.9%(34/41)in the treatment group and 80.0%(32/40)in the control group,suggesting that both groups were effective.There was no significant difference in clinical efficacy between the two groups(P>0.05),but the total effective rate in the treatment group was 2.9%higher than that in the control group.Conclusion Although there was no statistical difference in the integral and total effective rate between the treatment group and the control group.The trend of integral and the value of total effective rate suggest that the effect of oral administration of traditional Chinese medicine at the most active time of the intestinal meridian based on the theory of midnight-noon ebb-flow is better than that at the conventional time,which provides a reference for clinical medication.With the increase of clinical observation sample size,the statistical differences are expected.

关 键 词：子午流注 活血化瘀 慢传输型便秘 

分 类 号：R574.62[医药卫生—消化系统]