新型冠状病毒肺炎患者的临床特征研究  

Study on clinical features of patients with corona virus disease 2019

作　　者：刘欣[1] 许岱诗 陈旭翔 何方平 陈小可 周旭辉[1] 李建林 周长青 符佳颖 杨欢[1] 王彤[1] Liu Xin;Xu Daishi;Chen Xuxiang;HeFangping;Chen Xiaoke;Zhou Xuhui;Li Jianlin;Zhou Changqing;Fu Jiaying;Yang Huan;Wang Tong(The Eighth Affiliated Hospital of Sun Yat-sen University,Shenzhen 518033,Guangdong,China)

机构地区：[1]中山大学附属第八医院,广东深圳518033

出　　处：《中国中西医结合急救杂志》2020年第1期32-34,共3页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

摘　　要：目的了解新型冠状病毒肺炎(简称新冠肺炎)患者的临床特征,为该疾病的早期防控、诊断及治疗提供重要依据.方法连续收集2020年1月24日至30日于中山大学附属第八医院就诊的新冠肺炎疑似患者的临床资料,2019-nCoV核酸检测阳性者作为新冠肺炎确诊组(12例),2019-nCoV核酸阴性者作为新冠肺炎疑似组(50例).回顾性分析两组的病历资料、实验室检查及辅助检查结果.结果新冠肺炎确诊组的年龄明显大于新冠肺炎疑似组〔(56.5±15.4)岁比(42.1±17.9)岁,P<0.05〕,其余临床特征比较差异均无统计学意义(均P>0.05);新冠肺炎确诊组均出现发热症状,其中咳嗽7例(占58.3%)、咳痰5例(占41.7%)、咽痛3例(占25.0%)、乏力2例(占16.7%)、肌痛1例(占8.3%).与新冠肺炎疑似组比较,新冠肺炎确诊组的白细胞计数〔WBC(×10^9/L):5.220(4.485,5.950)比8.415(5.448,12.620)〕、血小板计数〔PLT(×10^9/L):163.080±30.414比228.240±66.811〕、中性粒细胞计数〔×10^9/L:3.040(2.650,3.818)比5.310(3.433,10.488)〕、嗜酸粒细胞计数〔×10^9/L:0.025(0.003,0.478)比0.050(0.018,0.163)〕、嗜酸粒细胞比例〔(0.575±0.624)%比(1.236±1.408)%〕、嗜碱粒细胞计数〔×10^9/L:0.010(0.010,0.018)比0.020(0.010,0.040)〕、血小板压积〔0.153(0.135,0.170)%比0.211(0.172,0.258)%〕明显降低(均P<0.05),单核细胞比例〔(8.692±3.004)%比(6.189±2.511)%〕、超敏C-反应蛋白(hs-CRP)>10ng/L患者所占比例〔66.7%(8/12)比28.0%(14/50)〕明显升高(均P<0.05).12例2019-nCoV核酸检测阳性患者肺部CT均表现为肺部炎症,其中累及双侧10例(占83.3%),单侧2例(占16.7%);病灶位于胸膜下区6例(占50%),肺下叶4例(占33.3%),肺中叶2例(占16.7%),肺上叶2例(占16.7%),肺外带2例(占16.7%);肺部病变呈磨玻璃影11例(占91.7%),均为片状或斑片状.结论2019-nCoV核酸检测阳性患者多为中老年人,男性多见,以发热、咳嗽为主要症状.血常规、hs-CRP及胸部CT可作为新冠肺炎的Objective To analyze the clinical features of patients with corona virus disease 2019(COVID-19),and to provide important evidence for the early prevention,diagnosis and treatment of the disease.Methods The COVID-19 suspected patients admitted in the Eighth Affiliated Hospital of Sun Yat-sen University from January 24,2020 to January 30,2020 were collected.The patients with positive 2019 novel coronavirus(2019-nCoV)test results were selected as the COVID-19 confirmed group(12 cases),and those with negative test results were selected as COVID-19 suspected group(50 cases).The medical records,laboratory and supplementary examination results of the two groups were retrospectively analyzed.Results The age of COVID-19 confirmed group was significantly older than that of COVID-19 suspected group[(56.5±15.4)vs.(42.1±17.9)years,P<0.05],and there was no significant difference in other clinical features(all P>0.05).All the patients of COVID-19 confirmed group developed fever symptoms,and 7 cases of cough(58.3%),5 cases of sputum(41.7%),3 cases of sore throat(25.0%),2 cases of fatigue(16.7%),and 1 case of myalgia(8.3%).In the COVID-19 confirmed group,the white blood cell count[WBC(×10^9/L):5.220(4.485,5.950)vs.8.415(5.448,12.620)],platelet count[PLT(×10^9/L):163.080±30.414 vs.228.240±66.811],neutrophil count[×10^9/L:3.040(2.650,3.818)vs.5.310(3.433,10.488)],eosinophil count[×10^9/L:0.025(0.003,0.478)vs.0.050(0.018,0.163)],eosinophil percentage[(0.575±0.624)%vs.(1.236±1.408)%],basophil count[×10^9/L:0.010(0.010,0.018)vs.0.020(0.010,0.040)],and platelet specific volume[0.153(0.135,0.170)%vs.0.211(0.172,0.258)%]were significantly decreased compared with COVID-19 suspected group(all P<0.05),and the percentage of monocytes[(8.692±3.004)%vs.(6.189±2.511)%]and percentage of hypersensitive C-reactive protein(hs-CRP)>10 ng/L[66.7%(8/12)vs.28.0%(14/50)]significantly increased(all P<0.05).All 12 cases of 2019-nCoV positive patients had pneumonia with abnormal findings on chest CT,among which 10 cases with both sides infecti

关 键 词：2019新型冠状病毒 超敏C-反应蛋白 肺炎 胸部CT 

分 类 号：R73[医药卫生—肿瘤]