组织因子及血管内皮生长因子在弥漫大B细胞淋巴瘤中的表达及其临床意义  

Expressions of tissue factor and vascular endothelial growth factor in diffuse large B-cell lymphoma and their clinical significances

作　　者：江亚军[1] 朱贵华[1] 何耀[1] 柴星星[1] 杨小云[1] 孟凡静 庄万传[1] Jiang Yajun;Zhu Guihua;He Yao;Chai Xingxing;Yang Xiaoyun;Meng Fanjing;Zhuang Wanchuan(Department of Hematology,the Second People's Hospital of Lianyungang,Lianyungang 222006,China)

机构地区：[1]江苏省连云港市第二人民医院血液科,222006

出　　处：《白血病．淋巴瘤》2020年第1期45-49,共5页Journal of Leukemia & Lymphoma

基　　金：连云港市"521高层次人才工程"资助项目;连云港市"科教强卫工程"青年科技项目(QN1605)。

摘　　要：目的 探讨组织因子(TF)、血管内皮生长因子(VEGF)在弥漫大B细胞淋巴瘤(DLBCL)中的表达及其临床意义。方法 收集2010年1月至2017年12月连云港市第二人民医院诊断的80例DLBCL患者的临床资料并将30例反应性淋巴结增生(RLN)作为对照,采用免疫组织化学法检测两组TF及VEGF的表达水平。结果 DLBCL组TF、VEGF的阳性率较RLN组增高[TF:86.3%(69/80)比50.0%(15/30);VEGF:90.0%(72/80)比53.3%(16/30);均P<0.01]。TF与VEGF的表达呈正相关(r=0.704,P<0.05)。DLBCL组中不同性别、年龄、Hans亚型患者TF、VEGF阳性率比较,差异均无统计学意义(均P>0.05)。有B症状、乳酸脱氢酶(LDH)增高、体力状态分级≥2级、结外病灶数>1处DLBCL患者的TF阳性率较高,差异均有统计学意义(均P<0.05)。Ann Arbor Ⅲ~Ⅳ期、有B症状、LDH增高、结外病灶数>1处DLBCL患者的VEGF阳性率较高,差异均有统计学意义(均P<0.05)。国际预后指数(IPI)评分高危组TF阳性率高于低危组(P<0.01);IPI高危组、高中危组VEGF阳性率均高于低危组(均P<0.01);TF、VEGF表达均与IPI评分呈正相关(r=0.491,P<0.01;r=0.529,P<0.01)。TF、VEGF低表达组DLBCL患者的总生存率均高于TF、VEGF高表达组(均P<0.05)。结论 TF和VEGF在DLBCL中高表达,且与IPI相关,对DLBCL的预后评估具有参考意义。Objective To investigate the expressions of tissue factor(TF)and vascular endothelial growth factor(VEGF)in diffuse large B-cell lymphoma(DLBCL)and their clinical significances.Methods The clinical data of 80 cases of DLBCL diagnosed at the Second People's Hospital of Lianyungang from January 2010 to December 2017 were collected,and 30 cases of reactive hyperplasia of lymph node(RLN)were selected as the controls.The expressions of TF and VEGF in the two groups were detected by using immunohistochemical staining.Results The positive rate of TF and VEGF in the DLBCL group was higher than that in the RLN group[TF:86.3%(69/80)vs.50.0%(15/30);VEGF:90.0%(72/80)vs.53.3%(16/30);both P<0.01].And there was a positive correlation between the expression of TF and VEGF(r=0.704,P<0.05).There was no significant difference in the positive rates of TF and VEGF among the patients with different gender,age and Hans subtypes in DLBCL group(all P>0.05).The positive rate of TF in DLBCL patients with B symptom,increased LDH,physical status grade≥2,and extranodal lesion number>1 was higher(all P<0.05).The positive rate of VEGF in patients with Ann Arbor stageⅢ-Ⅳ,B symptom,increased LDH,and extranodal lesion number>1 was higher(all P<0.05).The positive rate of TF in international prognostic index(IPI)high-risk group was higher than that in low-risk group(P<0.01);the positive rate of VEGF in IPI high-risk group and middle-high-risk group was higher than that in low-risk group(all P<0.01).The expressions of TF(r=0.491,P<0.01)and VEGF(r=0.529,P<0.01)were positively correlated with IPI.The overall survival rates of TF and VEGF low-expression group were higher than those of TF and VEGF high-expression group(both P<0.05).Conclusion The expressions of TF and VEGF are highly expressed in DLBCL,which is associated with the IPI.It can provide a reference value in evaluating prognosis of DLBCL.

关 键 词：淋巴瘤 大B细胞 弥漫性 血管内皮生长因子类 组织因子 国际预后指数 

分 类 号：R733[医药卫生—肿瘤]