曲美布汀联合兰索拉唑片治疗胃食管反流病的临床效果  

Clinical effect of trimebutin combined with lansoprazole tablets in the treatment of gastroesophageal reflux disease

作　　者：徐兴会 高红霞 XU Xing-hui;GAO Hong-xia(Luochuan Hospital of Traditional Chinese Medicine,Yan'an 727400;Yan'an Bo'ai Hospital,Yan'an 716000,China)

机构地区：[1]延安市洛川县中医医院,陕西延安727400 [2]延安市博爱医院,陕西延安716000

出　　处：《临床医学研究与实践》2020年第7期51-53,共3页Clinical Research and Practice

摘　　要：目的探讨曲美布汀联合兰索拉唑片治疗胃食管反流病的临床效果。方法选择2017年6月至2019年6月我院接收并诊治的80例胃食管反流病患者为研究对象,按随机数字法将其分为质子泵抑制剂组和联合治疗组,每组40例。质子泵抑制剂组采用兰索拉唑片治疗,联合治疗组采用马来酸曲美布汀片联合兰索拉唑片治疗。比较两组患者的治疗效果。结果治疗前,两组患者的GerdQ、GERD-HRQL各项评分比较,差异无统计学意义(P>0.05);治疗8周后,两组患者的GerdQ、GERD-HRQL各项评分均明显降低,且联合治疗组低于质子泵抑制剂组,差异具有统计学意义(P<0.05)。治疗前,两组患者的LESP、蠕动性收缩比例、LESRR及DCI比较,差异无统计学意义(P>0.05);治疗8周后,两组患者的LESP、蠕动性收缩比例、LESRR及DCI均明显升高,且联合治疗组高于质子泵抑制剂组,差异具有统计学意义(P<0.05)。治疗8周后,联合治疗组的治疗总有效率明显高于质子泵抑制剂组,差异具有统计学意义(P<0.05)。结论曲美布汀联合兰索拉唑片治疗胃食管反流病的临床效果显著,值得临床推广应用。Objective To investigate the clinical effect of trimebutin combined with lansoprazole tablets in the treatment of gastroesophageal reflux disease.Methods Eighty patients with gastroesophageal reflux disease admitted and treated in our hospital from June 2017 to June 2019 were selected as the study objects.The patients were divided into proton pump inhibitor group and combined treatment group according to the random number method,with 40 patients in each group.The proton pump inhibitor group was treated with lansoprazole tablets,and the combined treatment group was treated with trimebutin combined with lansoprazole tablets.The therapeutic effects of the two groups were compared.Results Before treatment,there were no significant differences in the scores of GerdQ and GERD-HRQL between the two groups(P>0.05);after 8 weeks of treatment,the scores of GerdQ and GERD-HRQL in both groups decreased significantly,and those in the combined treatment group were lower than the proton pump inhibitor group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in LESP,peristaltic contraction ratio,LESRR and DCI between the two groups(P>0.05);after 8 weeks of treatment,LESP,peristaltic contraction ratio,LESRR and DCI in both groups increased significantly,and those in the combined treatment group were higher than the proton pump inhibitor group,the differences were statistically significant(P<0.05).After 8 weeks of treatment,the total effective rate of treatment in the combined treatment group was significantly higher than that of the proton pump inhibitor group,and the difference was statistically significant(P<0.05).Conclusion Trimebutin combined with lansoprazole tablets in the treatment of gastroesophageal reflux disease has a significant clinical effect,which is worthy of clinical promotion and application.

关 键 词：胃食管反流病 曲美布汀 质子泵抑制剂 兰索拉唑 

分 类 号：R571[医药卫生—消化系统]