认知行为联合草酸艾司西酞普兰治疗抑郁症的效果  

Effect of cognitive behavior combined with Escitalopram Oxalate in the treatment of depression

作　　者：郑会民[1] 冯冬梅[1] 代娟[1] 梁颂游[1] ZHENG Hui-min;FENG Dong-mei;DAI Juan;LIANG Song-you(Department of Psychology,Zhongshan People's Hospital,Guangdong Province,Zhongshan 528400,China)

机构地区：[1]广东省中山市人民医院心理科,广东中山528400

出　　处：《中国当代医药》2020年第9期61-63,67,共4页China Modern Medicine

基　　金：广东省中山市医学科研项目(2019A020175)。

摘　　要：目的探究认知行为联合草酸艾司西酞普兰治疗抑郁症的效果。方法选取2018年1月~2019年5月我院收治的88例抑郁症患者,将2018年1~9月入院的患者设为对照组(n=44,应用单一草酸艾司西酞普兰治疗),而2018年10月~2019年5月入院的患者设为联合组(n=44,应用认知行为联合草酸艾司西酞普兰治疗),观察两组患者治疗后不同时间点的汉密尔顿焦虑量表(HAMD)、临床疗效总体量表之病情严重程度(CGI-SI)以及汉密尔顿焦虑量表(HAMA)评分情况。结果在治疗的第2、4及8周,联合组患者的CGI-SI、HAMD以及HAMA评分均低于对照组;两组患者治疗第2、4及8周的CGI-SI、HAMD以及HAMA评分均低于治疗前;联合组的有效率高于对照组,差异有统计学意义(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论对抑郁症患者采用认知行为联合草酸艾司西酞普兰的方式治疗可以有效缓解病情严重程度,改善抑郁及焦虑情绪,对临床治疗抑郁症具有指导价值。Objective To explore effect of cognitive behavior combined with Escitalopram Oxalate in the treatment of depression.Methods A total of 88 patients with depression admitted to our hospital from January 2018 to May 2019 were selected.Patients admitted from January to September 2018 were set as control group(n=44,treated with Escitalopram Oxalate),while patients admitted from October 2018 to May 2019 were set as combination group(n=44,treated with cognitive behavioral therapy combined with Escitalopram Oxalate),the clinical global impression-severity of illness(CGI-SI),Hamilton depression scale(HAMD)and Hamilton anxiety scale(HAMA)scores of depression patients in two groups at different time points after treatment were observed.Results At 2,4 and 8 weeks treatment,the CGI-SI,HAMD and HAMA scores of patients in the combined group were lower than those in the control group;at 2,4 and 8 weeks treatment,the CGI-SI,HAMD and HAMA scores of the two groups were lower than those before treatment,the effective rate of the combination group was higher than that of the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the total incidence rate of adverse reactions between the two groups(P>0.05).Conclusion Cognitive behavior combined with Escitalopram Oxalate for patients with depression can effectively alleviate the severity of depression and improve depression and anxiety,which has guidance value in clinical treatment of depression.

关 键 词：抑郁症 认知行为 草酸艾司西酞普兰 治疗效果 

分 类 号：R749.41[医药卫生—神经病学与精神病学]