γ-catenin alleviates cardiac fibrosis through inhibiting phosphorylation of GSK-3β  

作　　者：Xin Tang Jiaxin Tian Liping Xie Yong Ji 

机构地区：[1]Key Laboratory of Cardiovascular and Cerebrovascular Medicine,Key Laboratory of Targeted Intervention and Cardiovascular Disease,Collaborative Innovation Center for Cardiovascular Disease Translational Medicine,Nanjing Medical University,Nanjing,Jiangsu 211166,China

出　　处：《The Journal of Biomedical Research》2020年第1期27-35,共9页生物医学研究杂志（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(Grant No.81670209)。

摘　　要：Cardiac fibrosis is a common pathological change of many cardiovascular diseases. β-catenin has been shown to promote fibrosis. However, the precise role of its homolog γ-catenin in the process of fibrosis remains largely unclear. In this study, we found that the expression of γ-catenin was significantly decreased in angiotensin Ⅱ(Ang Ⅱ)-induced cardiac fibrosis model, contrary to most reports of β-catenin. Overexpression of γ-catenin in cardiac fibroblasts(CFs) significantly inhibited the expression of α-smooth muscle actin(α-SMA), whereas knocking down the expression of γ-catenin with si RNA promoted the occurrence of cardiac fibrosis.Mechanistically, γ-catenin could bind to GSK-3β to inhibit the phosphorylation of GSK-3β, therefore preventing cardiac fibrosis. Our study shows that γ-catenin is an important protective factor in cardiac fibrosis, which provides a new potential target for the treatment of cardiac fibrosis.Cardiac fibrosis is a common pathological change of many cardiovascular diseases. β-catenin has been shown to promote fibrosis. However, the precise role of its homolog γ-catenin in the process of fibrosis remains largely unclear. In this study, we found that the expression of γ-catenin was significantly decreased in angiotensin Ⅱ(Ang Ⅱ)-induced cardiac fibrosis model, contrary to most reports of β-catenin. Overexpression of γ-catenin in cardiac fibroblasts(CFs) significantly inhibited the expression of α-smooth muscle actin(α-SMA), whereas knocking down the expression of γ-catenin with si RNA promoted the occurrence of cardiac fibrosis.Mechanistically, γ-catenin could bind to GSK-3β to inhibit the phosphorylation of GSK-3β, therefore preventing cardiac fibrosis. Our study shows that γ-catenin is an important protective factor in cardiac fibrosis, which provides a new potential target for the treatment of cardiac fibrosis.

关 键 词：Γ-CATENIN CARDIAC FIBROSIS GSK-3Β 

分 类 号：R54[医药卫生—心血管疾病]