姜黄素联合奥沙利铂治疗转移性结肠癌的疗效及安全性临床分析  

Clinical analysis on curative effect and safety of curcumin combined with oxaliplatin in the treatment of metastatic colon cancer

作　　者：童秀萍[1] 吴深宝[1] TONG Xiuping;WU Shenbao(Department of Gastroenterology,Yiwu Central Hospital in Zhejiang Province,Jinha322000,China)

机构地区：[1]浙江省义乌市中心医院消化内科,浙江金华322000

出　　处：《中国现代医生》2020年第5期107-110,共4页China Modern Doctor

基　　金：浙江省科技计划项目(2017C33179)。

摘　　要：目的探讨姜黄素联合奥沙利铂治疗转移性结肠癌(Patients with metastatic colorectal cancer,mCRC)的疗效与安全性。方法选取2014年1月~2019年6月我院确诊为结肠癌的160例患者,将患者随机分为对照组和观察组,每组80例。两组均给予奥沙利铂治疗,观察组在此基础上加用姜黄素治疗,比较两组患者的肿瘤标志物水平、治疗有效率及不良反应。结果观察组治疗总有效率高于对照组,且不良反应发生率低于对照组,两组比较差异有统计学意义(P<0.05),两组肿瘤标志物水平均低于治疗前,且观察组更低,两组比较差异均有统计学意义(P<0.05)。结论姜黄素联合奥沙利铂治疗转移性结肠癌的治疗效果好且安全性较高。Objective To investigate the efficacy and safety of curcumin combined with oxaliplatin in the treatment of patients with metastatic colorectal cancer(mCRC).Methods 160 patients with colon cancer diagnosed in our hospital from January 2014 to June 2019 were selected.The patients were randomly divided into control group and observation group,with 80 cases in each group.Both groups were given oxaliplatin for treatment.The observation group was further given curcumin on this basis.The tumor marker level,effective rate and adverse reactions were compared between the two groups.Results The total effective rate in the observation group was higher than that in the control group,and the incidence rate of adverse reactions was lower than that in the control group.The difference between the two groups was statistically significant(P<0.05).The levels of tumor markers in the two groups were lower than those before treatment,and the observation group was lower.The difference between the two groups was statistically significant(P<0.05).Conclusion Curcumin combined with oxaliplatin in the treatment of metastatic colon cancer has a favorable therapeutic effect and higher safety.

关 键 词：转移性 结肠癌 姜黄素 奥沙利铂 

分 类 号：R735.35[医药卫生—肿瘤]