CD4^+CD25^high调节T细胞在膀胱癌微环境中的检测及临床意义  

Expression and clinical significance of CD4^+CD25^high regulatory T cells in microenvironment of bladder cancer

作　　者：张强 李进铭 刘俊波 谢超帆 杨雪松[1] ZHANG Qiang;LI Jin-ming;LIU Jun-bo;XIE Chao-fan;YANG Xue-song(Department of Urology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China)

机构地区：[1]川北医学院附属医院泌尿外科,四川南充637000

出　　处：《现代泌尿外科杂志》2020年第4期316-318,333,共4页Journal of Modern Urology

基　　金：南充市市校科技战略合作项目(No.18SXHZ0538);南充市市校科技战略合作项目(No.19SXHZ0332)。

摘　　要：目的分析CD4^+CD25^highTreg细胞在膀胱癌及正常膀胱组织中的分布及其意义。方法通过免疫组织化学法,分析80例膀胱癌患者及50例正常膀胱组织中CD4^+CD25^highTreg细胞的分布差异情况,并探讨其与临床病理特征之间的相关性。结果相较于正常的膀胱组织,膀胱癌组织中CD4^+CD25^high Treg细胞所占百分比[(34.79±1.05)%]高于对照组[(7.86±0.82)%],差异具有显著统计学意义。CD4^+CD25^high Treg细胞含量与肿瘤的病理分级呈正相关,差异具有统计学意义(P=0.02),CD4^+CD25^highTreg细胞在膀胱肿瘤微环境中的分布情况与性别、年龄、淋巴转移之间无统计学差异(P>0.05)。结论 CD4^+CD25^highTreg细胞在膀胱癌组织中的含量显著增加,且与膀胱肿瘤的病理分级呈相关性,其揭示CD4^+CD25^high Treg细胞含量的增加可能与疾病的发生与进展有关。Objective To analyze the expression and significance of CD4^+CD25^high regulatory T cells in bladder cancer and normal bladder tissues.Methods The expression of CD4^+CD25^high regulatory T cells in80 cases of bladder cancer and50 cases of normal bladder tissues was analyzed with immunohistochemistry,and the correlation between expression of CD4^+CD25^high regulatory T cells and clinicopathological features was discussed.Results Bladder cancer tissues had significantly higher percentage of CD4^+CD25^high regulating T cells than normal bladder tissues[(34.79±1.05)% vs.(7.86±0.82)%].The expression of CD4^+CD25^high regulated T cells was positively correlated with pathological grade of bladder tumors(P=0.02),but not with gender,age or lymphatic metastasis(P>0.05).Conclusion CD4^+CD25^high regulatory T cells are highly expressed in bladder cancer tissues,which is correlated with the pathological grade of bladder cancer.The increase of CD4^+CD25^high regulatory T cells may be related to the pathogenesis and progression of bladder cancer.

关 键 词：膀胱肿瘤 免疫抑制 细胞因子 T淋巴细胞 FOXP3 

分 类 号：R737.14[医药卫生—肿瘤]