NDRG2基因抑制肿瘤细胞增殖机制的研究进展  

Research of mechanism of NDRG2 gene inhibiting tumor cell proliferation

作　　者：苏志航 吴舟 SU Zhi-hang;WU Zhou(Department of Urology,the Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,Guangdong,CHINA)

机构地区：[1]广东医科大学附属医院泌尿外科,广东湛江524001

出　　处：《海南医学》2020年第7期918-921,共4页Hainan Medical Journal

基　　金：广东省湛江市财政专项备用金项目(编号:2016C01019)。

摘　　要：NDRG2属于NDRG (N-Myc下游调节基因)家族,是我国学者首先从人脑内克隆的一种新型广谱抑癌基因,在多种人类恶性肿瘤中发挥抑制作用。目前,NDRG2抑制肿瘤细胞增殖机制的研究主要涉及信号转换领域,而能量代谢方面的研究则很少,有待进一步研究。本文对NDRG2基因抑制肿瘤细胞增殖的机制进行综述。NDRG2, belongs to the NDRG(N-Myc downstream regulatory gene) family, is a novel broad-spectrum tumor suppressor gene cloned from human brain by Chinese scholars, which plays an inhibitory role in many human malignant tumors. At present, the research on the mechanism of NDRG2 inhibiting tumor cell proliferation mainly involves the field of signal transduction, while the research on energy metabolism is rare, further research is needed. This article reviews the mechanism of NDRG2 gene inhibiting tumor cell proliferation.

关 键 词：NDRG2 抑制 肿瘤细胞 增殖 进展 

分 类 号：R73-37[医药卫生—肿瘤]