Injury of the dentatorubrothalamic tract in patients with post-traumatic tremor following mild traumatic brain injury: a case-control study  

作　　者：Sung Ho Jang Han Do Lee 

机构地区：[1]Department of Physical Medicine and Rehabilitation,College of Medicine,Yeungnam University,Daegu,Republic of Korea [2]Department of Physical Medicine and Rehabilitation,College of Natural Science,Ulsan College University,Ulsan,Republic of Korea

出　　处：《Neural Regeneration Research》2020年第11期2063-2066,共4页中国神经再生研究（英文版）

基　　金：supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(NRF-2018R1A6A3A11043447,to HDL)。

摘　　要：Post-traumatic movement disorder is one of the sequelae of traumatic brain injury. The dentatorubrothalamic tract(DRTT) is reported to be involved in the control of movement. Therefore, injury of the DRTT can be accompanied by abnormal movements, including ataxia, tremor, or dystonia. We investigated DRTT injuries in 27 patients who showed post-traumatic tremor in at least one of four extremities following mild traumatic brain injury. We classified DRTT injuries based on diffusion tensor tractography parameters and configuration: type A: the DRTT showed narrowing, type B: the DRTT showed partial tearing, and type C: the DRTT showed discontinuation. Fractional anisotropy and fiber number of the DRTT were significantly decreased in patients compared with the healthy controls. Based on our DRTT injury classification, among the 54 hemispheres of the 27 patients, type A injury occurred in 22 hemispheres(40.7%) of 17 patients, type B injury was present in 15 hemispheres(27.7%) of 10 patients, and type C injury was observed in 8 hemispheres(14.8%) of 6 patients. Our results suggest that diffusion tensor tractography-based evaluation of the DRTT would be useful when determining cause of post-traumatic tremor in patients with mild traumatic brain injury. The study protocol was approved by the Institutional Review Board of Yeungnam University Hospital(YUMC-2018-09-007) on September 5, 2018.

关 键 词：dentatorubrothalamic TRACT DIFFUSION TENSOR imaging DIFFUSION TENSOR tractography fiber number fractional anisotropy mild traumatic brain INJURY POST-TRAUMATIC TREMOR region of interest 

分 类 号：R651.15[医药卫生—外科学]