不同化疗方案联合调强适形放疗治疗鼻咽癌的临床疗效  

Clinical efficacy of different kinds of chemotherapy combined with intensity modulated radiotherapy in the treatment of Nasopharyngeal carcinoma

作　　者：龚玉爱 舒诚荣 王汉姣 韩琦 郭宗华 Gong Yuai;Shu Chengrong;Wang Hanjiao;Han Qi;Guo Zonghua(Department of Oncology,Xianning Central Hospital,Xianning,Hubei,437100,China;Department of Urology,Xianning Central Hospital,Xianning,Hubei,437100,China)

机构地区：[1]咸宁市中心医院肿瘤科,湖北咸宁437100 [2]咸宁市中心医院泌尿外科,湖北咸宁437100

出　　处：《当代医学》2020年第12期81-83,共3页Contemporary Medicine

摘　　要：目的观察鼻咽癌患者采用GP(吉西他滨、顺铂)、PF(顺铂、氟尿嘧啶)及TPF(多西他赛、顺铂、氟尿嘧啶)方案化疗联合调强适形放疗(IMRT)治疗的临床治疗效果。方法选取2012年1月至2014年1月本院收治的120例鼻咽癌患者作为研究对象,根据不同治疗方案分为一组、二组、三组,各40例。一组患者采用GP化疗联合IMRT治疗,二组采用PF化疗联合IMRT治疗,三组采用TPF化疗联合IMRT治疗。随访5年,比较3组患者的5年生存率、无病生存率、局部无复发生存率及不良反应发生率。结果一组、二组、三组患者的5年生存率分别为95.00%、82.50%、97.50%,一组、二组、三组患者的无病生存率分别为80.00%、60.00%、77.50%,一组、二组、三组患者的局部无复发生存率分别为92.50%、72.50%、90.00%;一组、三组患者5年生存率明显高于二组,且一组患者不良反应发生率<二组<三组,差异有统计学意义(P<0.05)。结论GP化疗联合IMRT、TPF化疗联合IMRT对鼻咽癌疗效明显优于PF化疗联合IMRT,TPF化疗联合IMRT方案与GP化疗联合IMRT方案对鼻咽癌疗效相当,但是不良反应更多。Objective To observe the effects of GP(gemcitabine,cisplatin),PF(cisplatin,fluorouracil)and TPF(docetaxel,cisplatin)on nasopharyngeal carcinoma(NPC).Clinical efficacy of chemotherapy combined with intensity modulated conformal radiotherapy(IMRT)in the treatment of fluorouracil.Methods From January 2012 to January 2014,120 patients with nasopharyngeal carcinoma were selected and divided into one group,two group and three group according to different treatment schemes,with 40 cases in each group.The patients in one group were treated with GP chemotherapy combined with IMRT,two group were treated with PF chemotherapy combined with IMRT,and three group were treated with TPF chemotherapy combined with IMRT.The five-year survival rate,disease-free survival rate,local relapse-free survival rate and side effect rate were compared among the three groups.Results The five-year survival rates of one group,two group and three group were 95.00%,82.50%,97.50%,respectively,the disease-free survival rate of one group,two group and three group was 80.00%,60.00%,77.50%,respectively.The local relapse-free survival rates in one group,two group and three group were 92.50%,72.50%and 90.00%,respectively.The five-year survival rate of the patients in one group and three groups was significantly higher than that in the two group,and the toxicity and side effects occurred in one group.The incidence of toxic side effects in one group was<two group<three group,and the difference was statistically significant(P<0.05).Conclusion The curative effect of GP chemotherapy combined with IMRT,TPF chemotherapy combined with IMRT on nasopharyngeal carcinoma is better than that of PF chemotherapy combined with IMRT,TPF chemotherapy combined with IMRT regimen and GP chemotherapy combined with IMRT regimen on nasopharyngeal carcinoma,but there are more toxic and side effects.

关 键 词：鼻咽癌 GP方案 化疗 IMRT PF方案 临床疗效 TPF方案 

分 类 号：R739.63[医药卫生—肿瘤]