肿瘤坏死因子和血管紧张素Ⅱ与慢性肝衰竭患者并Ⅰ型HRS肝肾功能相关性分析  

The correlation research on the type 1 HRS with levels of TNF-αand AngⅡin CLF patients

作　　者：邹波[1] 谢能文[1] 张雪珍[1] Zou Bo;Xie Nengwen;Zhang Xuezhen(First Department of Liver Disease,Hospital 9th of Nanchang,Nanchang,Jiangxi,330002,China)

机构地区：[1]南昌市第九医院肝一科,江西南昌330002

出　　处：《当代医学》2020年第12期93-95,共3页Contemporary Medicine

摘　　要：目的检测慢性肝衰竭(chronic liver failure,CLF)与Ⅰ型肝肾综合征(hepatorenal syndrome,HRS)患者血清肿瘤坏死因子-α(TNF-α)、血管紧张素Ⅱ(AngⅡ)水平变化,并进行TNF-α、AngⅡ与肝肾功能的相关性分析。方法选取2014年6月至2018年12月于本院住院的CLF并Ⅰ型HRS患者30例(CLF+HRS组),另选取同期住院的CLF无肾功能损害的患者30例(CLF组),检测对比两组患者肝肾功能指标、血清TNF-α、AngⅡ含量,并与肝肾功能指标水平进行相关性分析。结果CLF+HRS组TNF-α、AngⅡ、Scr水平均高于CLF组,Ccr水平低于CLF组,差异具有统计学意义(P<0.05);两组各项肝功能指标比较差异无统计学意义;两组患者血清TNF-α、AngⅡ含量与Scr、TBIL呈正相关,与Ccr、PTA呈负相关(P<0.05)。结论TNF-α、AngⅡ水平均与CLF患者Ⅰ型HRS密切相关。Objective To detect serum tumor necrosis factor-α(TNF-α) and angiotensin Ⅱ(AngⅡ) in patients with chronic liver failure(CLF)and type I hepatorenal syndrome(HRS) level changes, and correlation analysis between TNF-α, AngⅡ and liver and kidney function. Methods 30 patients with CLF without renal impairment(CLF group) and 30 patients with CLF and type I HRS(CLF+HRS group) who were hospitalized in Ninth Hospital of Nanchang from June 2014 to December 2018 were selected. The liver and kidney function indexes, serum TNF-α and AngⅡ levels were measured and compared in the two groups, and the correlation between TNF-α and AngⅡ levels and liver and kidney function was analyzed.Results The levels of TNF-α, AngⅡ and Scr in CLF+HRS group were higher than those in CLF group, and the levels of Ccr were lower than those in CLF group, with statistical significance(P<0.05). There was no significant difference in liver function between the two groups. The serum levels of TNF-α and AngⅡ were positively correlated with Scr and TBIL, negatively correlated with CCr and PTA(P<0.05). Conclusion TNF-α and AngⅡ levels are closely related to patients with CLF combined 1 HRS.

关 键 词：慢性肝衰竭 肝肾综合征 肿瘤坏死因子-α 血管紧张素Ⅱ 

分 类 号：R575.3[医药卫生—消化系统] R692[医药卫生—内科学]