针刺穴位效应启动的初始动力学调控机制  

The Initiating Dynamic Regulation Mechanism of Acupuncture in Acupoint Effects

作　　者：赵雪[1,2] 郭义 郭永明[1,2] 陈波 刘阳阳[1,2] 周丹 席强[1,2] 李忠正 张阔[1,3] 王秀云 徐汤苹[1] 潘萍 陈静子[1] 高轶 裴莹[1] 张秀玉 康婧青[1] 王雪争 陈静霞[1] 刘亚丽 肖淑华[1] 李晓梅[1] 崔瑞[1] 刘敬[1] 潘丽佳[1] 张玄[1] 安琪[1] 马思宇[1] 闫雅雯[1] 杨涛[1] 邢丽莹 徐舒亭[1] ZHAO Xue;GUO Yi;GUO Yongming;CHEN Bo;LIUYangyang;ZHOU Dan;XI Qiang;LI Zhongzheng;ZHANG Kuo;WANg Xiuyun;XU Tangping;PAN Ping;CHEN Jingzi;GAO Yi;PEI Ying;ZHANG Xiuyu;KANG Jingqing;WANG Xuezheng;CHEN Jingxia;LIU Yali;XIAO Shuhua;LI Xiaomei;CUI Rui;LIU Jing;PAN Lijia;ZHANG Xuan;AN Qi;MA Siyu;YAN Yawen;YANG Tao;XING Liying;XU Shuting(Experimental Acupuncture Research Center,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;National TCM Acupuncture and Moxibustion Clinical Research Center,Tianjin 300193,China;Academy of Medical Engineering and Translational Medicine,Tianjin University,Tianjin 300072,China)

机构地区：[1]天津中医药大学实验针灸学研究中心,天津301617 [2]国家中医针灸临床医学研究中心,天津300193 [3]天津大学医学工程与转化医学研究院,天津300072

出　　处：《世界中医药》2020年第7期997-1002,共6页World Chinese Medicine

基　　金：“八五”国家科技攻关计划项目(3850016);国家“八五”攀登计划项目(JL93015);国家重点基础研究发展计划(973计划)项目(2005CB523308);国家自然科学基金重点项目(81330088,50537030);国家自然科学基金面上项目(81173204,30772838);国家自然科学基金青年基金项目(39100138,81303025,81102641,81403457,81503636,81603677);教育部高等学校博士学科点专项科研基金项目(20101210110007);天津市重点实验室资助项目(2004zd13);天津市自然科学基金项目(15JCQNJC10800,18JCQNJC82400)。

摘　　要：针刺效应是如何启动的,是针刺作用原理研究中的共性关键问题。多年来在肯定针刺效应的前提下,从穴位局部化学离子入手,由点及线,由线成网,从神经、免疫、内分泌、能量代谢不同角度开展研究,探讨了局部神经-细胞-化学物质的相互作用,系统研究了针刺后“穴网络”变化其与针刺效应的关系,证实:1)针刺可引起支配穴位的神经兴奋,启动神经调节;2)针刺可引发穴位局部炎性反应,启动免疫调节;3)针刺可调节穴区部分激素水平;4)针刺可调节穴区血流和氧分压,影响局部能量代谢;5)针刺后穴区神经-肥大细胞-化学物质相互作用,影响针刺效应;6)有向加权模型和复杂网络模型能够刻画针效初始调控网络的时序响应特征,并发现其中关键节点。对针效启动机制的研究,应将局部反应与整体效应相结合,建立起相互联系、相互影响的复杂网络概念,进行系统的归纳和规律的提炼,从而揭示针效启动的关键基础因素,探寻针刺效应的有效调控模式,提高针刺的临床疗效。How the acupuncture effects is initiated is a common key issue in the study of the acupuncture action principle.For many years,under the affirmative acupuncture effects,starting with the local chemical ions at the acupoints,from dots to lines,and from lines to nets,the research was conducted from different angles of nerve,immunity,endocrine,and energy metabolism,exploring local nerve-cell-chemical interaction and systematically studying“Acupuncture Network”changes and its relationship with acupuncture effects.It has been proved that:1)Acupuncture could excite nerves that innervating acupoints thus initiate neuroregulation.2)Acupuncture could induce local inflammatory reaction of acupoint and initiate immune regulation.3)Acupuncture could regulate the levels of some hormones in acupoint area.4)Acupuncture could regulate blood flow and partial pressure of oxygen in acupoint area,thus affecting local energy metabolism.5)The post-interaction of nerve-mast cell-chemical substances in acupoint area influences acupuncture effects.6)The directed weighting model and the complex network model are supposed to describe the time series response characteristics of the initiation regulatory network of acupuncture,and locate the key signaling molecules.In the study of the initiation mechanism of acupuncture effects,we should combine the local reaction with the whole effects,establish the interactional,mutually connected concept of complex network.And based on systematic summarization and abstraction,we uncovered the key basic factors of acupuncture,acquiring its effective regulation mode and finally improving its clinical efficacy of acupuncture.

关 键 词：针刺效应 穴位 启动机制 针刺原理 

分 类 号：R245-0[医药卫生—针灸推拿学]