精神分裂症发病机制相关基因多态性研究进展  

Progress in Study of Gene Polymorphisms Related to Schizophrenia Pathogenesis

作　　者：周岑 王晓东[1] 沈丽[1] 王冬思 王春涛[1] ZHOU Cen;WANG Xiaodong;SHEN Li;WANG Dongsi;WANG Chuntao(Mudanjiang Medical University,Mudanjiang 157011,China)

机构地区：[1]牡丹江医学院,黑龙江牡丹江157011

出　　处：《医学综述》2020年第8期1553-1557,1562,共6页Medical Recapitulate

基　　金：牡丹江市科学技术计划项目(Z2016s0102)。

摘　　要：精神分裂症的主要特征为患者出现严重的精神活动异常,多由遗传因素和环境因素协同作用导致,发病机制仍未明确。目前神经递质假说、神经发育障碍假说发病机制的相关基因与精神分裂症的关联研究已在国内外被广泛报道。这些研究在分子水平上评估基因单核苷酸多态性对精神分裂症发病及临床症状的影响,进而找出与疾病相关的易感基因。神经递质假说相关基因如多巴胺D3受体、5-羟色胺转运体和5-羟色胺受体1B基因以及神经发育障碍假说基因如转录因子配对盒6、Dickkopf相关蛋白4、N-脱乙酰基酶-N-磺基转移酶3和Musashi2基因均已被证明与精神分裂症发生、发展存在关联。Schizophrenia is characterized by the appearance of severe abnormal mental activities,which is mostly caused by both genetic and environmental factors,and its pathogenesis is still not clear.At present,the researches on the correlation between related genes in the pathogenesis hypotheses of neurotransmitter,neurodevelopmental disabilities and schizophrenia were widely reported.Previous studies tried to identify the susceptibility genes for schizophrenia at the molecular level,by illustrating the effects of single nucleotide polymorphisms on the onset and clinical symptoms of schizophrenia.The correlations of neurotransmitter hypothesis related genes such as dopamine receptor D3,solute carrier family 6 member 4 and 5-hydroxytryptamine receptor 1B,neurodevelopmental disability related genes paired box 6,Dickkopf WNT signaling pathway inhibitor 4,N-deacetylase and N-sulfotransferase 3,Musashi RNA binding protein 2 with the onset and development of schizophrenia have been verified.

关 键 词：精神分裂症 单核苷酸多态性 易感基因 

分 类 号：R749.3[医药卫生—神经病学与精神病学]