持续感染状态的HPV-16及HPV-58亚型在宫颈病变中的分布及危险因素  

The Distribution and Risk Factors of HPV-16 and HPV-58 Subtypes in Cervical Lesions with Persistent Infection

作　　者：刘群香 王莉 李江丽 LIU Qunxiang;WANG Li;LI Jiangli(Taihe Branch of the Southern Hospital in Guangzhou, Guangdong Guangzhou 510540,China)

机构地区：[1]广东省广州市南方医院太和分院妇产科,广东广州510540

出　　处：《河北医学》2020年第4期541-545,共5页Hebei Medicine

基　　金：广东省自然科学基金项目,(编号:2016A041510231)。

摘　　要：目的:分析宫颈病变持续感染状态下HPV-16与HPV-58亚型分布情况及导致其病变的危险因素。方法:选取2017年1月至2019年3月我院收治的宫颈病变患者100例作为观察组,另选我院体检正常患者90例作为对照组,分析观察组持续感染状态患者人乳头瘤病毒(Human papillomavirus,HPV)亚型HPV-16与HPV-58亚型的分布,并根据两组患者一般资料情况采用单因素与二元Logistic回归分析导致观察组患者宫颈病变的影响因素与独立危险因素。结果:宫颈癌患者占比最高HPV-16占比73.68%、HPV-58占比78.95%,宫颈上皮内瘤变Ⅱ~Ⅲ期HPV-16占比60.00%、HPV-58占比66.67%、宫颈上皮内瘤变I期HPV-16占比36.84%、HPV-58占比31.58%;宫颈炎HPV-16占比35.72%、HPV-58占比46.43%;不同类型宫颈病变患者HPV-16、HPV-58分布相较,差异具有统计学意义(P<0.05)。单因素与二元Logistic回归分析显示:初次性行为年龄、性伴侣数量、阴道炎症、宫颈癌家族史是导致宫颈病变的影响因素与独立危险因素。结论:宫颈病变持续感染状态下宫颈癌患者HPV-16与HPV-58亚型占比最多,其次为宫颈上皮内瘤变Ⅱ~Ⅲ期、Ⅰ期者,最少为宫颈炎患者。初次性行为年龄、性伴侣数量、阴道炎症、宫颈癌家族史是导致宫颈病变的独立危险因素,临床中对于该类患者需格外注意。Objective:The distribution of HPV-16 and HPV-58 subtypes and the risk factors leading to cervical lesions were analyzed.Methods:From January 2017 to March 2019,100 patients with cervical lesions were selected as observation group and 90 patients with normal physical examination as control group.The distribution of HPV-16 and HPV-58 subtypes of human papillomavirus(Human papillomavirus,HPV)subtypes in patients with persistent infection in the observation group was analyzed.According to the general data of the two groups,univariate and binary Logistic regression analysis was used to analyze the influencing factors and independent risk factors of cervical lesions in the observation group.Results:The highest proportion of cervical cancer patients was HPV-16(73.68%),HPV-58(78.95%),cervical intraepithelial neoplasia II-III(60.00%),HPV-58(66.67%),cervical intraepithelial neoplasia I(36.84%),HPV-58(31.58%),cervicitis(35.72%),HPV-58(46.43%);the distribution of HPV-16 and HPV-58 in different types of cervical lesions was statistically significant(P<0.05).Single factor and binary logistic regression analysis showed that age of first sexual behavior,number of sexual partners,vaginitis and family history of cervical cancer were the influencing factors and independent risk factors of cervical lesions.Conclusion:The proportion of HPV-16 and HPV-58 in the patients with cervical intraepithelial neoplasia(HPV-16)and HPV-58(HPV-58)in the patients with cervical intraepithelial neoplasia(HPV-16),followed by cervical intraepithelial neoplasia(II-III),I-phase,and at least cervicitis(Cervicitis).The age of initial sexual behavior,the number of sexual partners,the inflammation of the vagina,the family history of the cervical cancer are the independent risk factors that lead to the cervical lesion.

关 键 词：持续感染状态 人乳头瘤病毒 宫颈病变 

分 类 号：R73[医药卫生—肿瘤]