实施乙型肝炎疫苗免疫后济南地区25岁及以下人群乙型肝炎标志物的检测分析  

Detection and analysis of hepatitis B markers in population under 25 years old after hepatitis B vaccine immunization in Jinan

作　　者：姜健阁[1] 路其凤 沈亚娟[2] 杨西贤[2] 宋培 褚福禄[2] Jiang Jiangge;Lu Qifeng;Shen Yajuan;Yang Xixian;Song Pei;Chu Fulu(Department of lxiboratory,Dezhou People's Hospitaly Shandong Provincey Dezhou 253000,China;Department of Clinical Medicine Laboratory,Provincial Hospital Affiliated to Shandong University,Jinan 250000,China)

机构地区：[1]山东省德州市人民医院检验科,253000 [2]山东大学附属省立医院临床医学检验部,济南250000

出　　处：《中国医药》2020年第4期588-592,共5页China Medicine

基　　金：山东省自然科学基金(ZR2017MH088);山东省医药卫生科技发展计划(2017WS095)。

摘　　要：目的了解实施乙型肝炎疫苗(Hep B)接种纳入儿童计划免疫管理后济南地区25岁及以下人群的乙型肝炎标志物模式情况。方法回顾性分析2017年6月至2018年6月在山东大学附属省立医院就诊的25岁及以下患者血清标本6454份。按照年龄和性别分为0~14岁儿童组共3494份,其中男儿童组2071份,女儿童组1423份;15~25岁青少年组共2960份,其中男青少年组1315份,女青少年组1645份。检测所有患者乙型肝炎病毒五项指标,包括乙型肝炎表面抗原(HBs Ag)、乙型肝炎表面抗体(HBs Ab)、乙型肝炎e抗原、乙型肝炎e抗体、乙型肝炎核心抗体。结果0~25岁人群乙型肝炎模式可见19种,其中HBs Ab单阳性模式比例最高为58.72%(3790/6454),其次为五项全阴性者30.79%(1987/6454)。0~25岁HBs Ag携带率为3.33%(215/6454),其中0~14岁儿童组HBs Ag携带率为1.63%(57/3494),男儿童组HBs Ag携带率为1.40%(29/2071),女儿童组HBs Ag携带率为1.97%(28/1423),15~25岁青少年组HBs Ag携带率为5.34%(158/2960),男青少年组HBs Ag携带率为6.77%(89/1315),女青少年组HBs Ag携带率为4.19%(69/1645)。结论Hep B纳入儿童计划免疫后,有效降低了人群HBs Ag携带率。济南地区25岁及以下人群乙型肝炎标志物模式以HBs Ab单阳性为主,其次为全阴性者,男女无明显差异。Objective To investigate the pattern of hepatitis B markers among population under 25 years old in Jinan after the implementation of hepatitis B vaccine in children planned immunization. Methods A retrospective analysis was conducted on 6 454 serum samples from people under 25 years old who visited Shandong Provincial Hospital Affiliated to Shandong University from June 2017 to June 2018. According to age and sex,they were divided into 0-14 years old( n = 3 494) boys( n = 2 071) and girls( n = 1 423),15-25 years old( n = 2 960)boys(n = 1 315) and girls(n = 1 645). Hepatitis B surface antigen(HBs Ag),hepatitis B surface antibody(HBs Ab),hepatitis B e-antigen,hepatitis B e-antibody,hepatitis B core antibody were detected. Results There were 19 modes of hepatitis B markers combination among all subjects. HBs Ab single-positive rate was 58. 72%(3 790/6 454). Five indicators all-negative rate was 30. 79%(1 987/6 454). The carrying rate of HBs Ag was 3. 33%(215/6 454) in0-25 years old people. The carrying rate of HBs Ag was 1. 63%(57/3 494) in 0-14 years old children group,with1. 40%(29/2 071) in boys and 1. 97%( 28/1 423) in girls;it was 5. 34%( 158/2 960) in 15-25 years old adolescents group,with 6. 77%( 89/1 315) in boys and 4. 19%( 69/1 645) in girls. Conclusions HBs Ag carrying rate is significantly reduced after introducing hepatitis B vaccine into children planned immunization.HBs Ab single-positive is the main mode of hepatitis B markers among people aged 25 years and younger in Jinan area;all-negative is also common. There is no obvious difference between males and females.

关 键 词：乙型肝炎疫苗 乙型肝炎病毒标志物 计划免疫 

分 类 号：R575.1[医药卫生—消化系统]