儿童血管性肿瘤基因研究进展  

Advances in Genetic Studies of Childhood Vascular Tumors

作　　者：张斌[1] 马琳[1] ZHANG Bin;MA Lin(Department of Dermatology,Beijing Children’s Hospital,Capital Medical University,National Center for Children's health,Beijing 100045,China)

机构地区：[1]国家儿童医学中心,首都医科大学附属北京儿童医院皮肤科,北京100045

出　　处：《皮肤科学通报》2020年第1期78-85,共8页Dermatology Bulletin

基　　金：北京市医院管理局儿科学科协同发展中心专项基金(XTZD20180502);国家自然科学基金(81673042)。

摘　　要：儿童血管性肿瘤是一组临床表现复杂的血管内皮细胞增生性肿瘤,儿童期发病率高,其发病机制目前尚未明确。最近研究报道其许多亚型与相关致病基因的突变相关。本文对近年来儿童血管性肿瘤致病基因研究进展进行综述,旨在帮助临床工作者更好地理解这类疾病的发病机制,同时为靶向药物治疗提供理论依据。Childhood vascular tumors are neoplasms of endothelial cells,with complicated clinical manifestations,a significant number of which present in childhood.The pathogenesis of vascular tumors has not been clear yet.Recent studies have reported the mutational landscape of many subtypes of vascular tumors.In order to help clinical doctors to better understand the pathogenesis of vascular tumors and provide a theoretical foundation to consider targeted therapeutics,this article reviewed the research progress of pathogenic genes of childhood vascular tumors in recent years.

关 键 词：血管瘤 血管性肿瘤 发病机制 基因 

分 类 号：R732.2[医药卫生—肿瘤]