Structural dynamics of a plant NLR resistosome:transition from autoinhibition to activation  

作　　者：Jing Wang Mawsheng Chern Xuewei Chen 

机构地区：[1]State Key Laboratory of Hybrid Rice,Key Laboratory of Major Crop Diseases and Collaborative Innovation Center for Hybrid Rice in Yangtze River Basin,Rice Research Institute,Sichuan Agricultural University at Wenjiang,Chengdu,Sichuan 611130,China [2]Department of Plant Pathology,University of California,Davis,CA 95616,USA

出　　处：《Science China(Life Sciences)》2020年第4期617-619,共3页中国科学（生命科学英文版）

摘　　要：Despite the lack of a cellular,adaptive immune system,plants share with animals an innate immune system and can effectively fight off pathogen attack using two layers of defense response:the first layer consists of plasma membrane-localized pattern recognition receptors(PRRs)that recognize pathogen-associated molecular patterns(PAMPs)and can mount a pattern-triggered immunity(PTI);the second layer comprises cytoplasmic nucleotide-binding,leucine-rich repeats receptors(NLRs)that recognize pathogensecreted effectors and mount an effector-triggered immunity(ETI)(Shamrai,2014).Plants contain hundreds of NLR genes constituting one of the largest families of genes.Because plant NLR genes can mount the strongest immune response,often including a hypersensitive response,upon recognition of its cognate effector,they were initially characterized as resistance(R)genes and conform to the genefor-gene hypothesis postulated in 1955(Hh,1955;McHale et al.,2006).The plant NLR-mediated ETI response is thus comparable to the animal inflammatory response.

关 键 词：NLR IMMUNITY MOUNT 

分 类 号：Q943.2[生物学—植物学]