外泌体在脑缺血中的信号传递作用  

Signal transduction of exosomes in cerebral ischemia

作　　者：吴茂东 杜海敏 赵秦 陆飞[1] 张广慧 孙振杰 Wu Maodong;Du Haimin;Zhao Qin;Lu Fei;Zhang Guanghui;Sun Zhenjie(Lianyungang Hospital Affiliated to Nanjing Medical University,the First People's Hospital of Lianyungang,Lianyungang 222000,China)

机构地区：[1]南京医科大学附属连云港医院,连云港市第一人民医院,222000

出　　处：《国际脑血管病杂志》2020年第2期145-149,共5页International Journal of Cerebrovascular Diseases

基　　金：中国博士后科学基金(m601759);江苏省博士后科研资助计划(m1701011c)。

摘　　要：外泌体是由各种细胞来源释放的细胞外囊泡,广泛存在于体液中。外泌体内部包裹微RNAs、mRNAs和蛋白质等生物活性物质,可激活各类信号通路,在卒中预警和神经血管单元修复中发挥重要作用。文章对外泌体在脑缺血中的信息传递作用进行了综述。Exosomes are extracellular vesicles released from various cellular sources and are widely present in body fluids.Bioactive substances such as microRNAs,mRNAs,and proteins are encapsulated in exosomes,which can activate various signaling pathways and play important roles in early warning of stroke and neurovascular unit repair.This article reviews the signal transduction of exosomes in cerebral ischemia.

关 键 词：外泌体 神经血管单元 微RNAS 脑缺血 生物活性物质 细胞外囊泡 信号通路 细胞来源 

分 类 号：R74[医药卫生—神经病学与精神病学]