经尿道同期电切膀胱肿瘤和良性前列腺增生组织患者的安全性和生活质量分析  

The safety and quality of life in benign prostatic hyperplasia patients undergoing simultaneous transurethral resection of bladder tumor and transurethral prostatectomy

作　　者：石昌龙 宋永胜[1] Shi Changlong;Song Yongsheng(Department of Urology,Shengjing Hospital of China Medical University,Liaoning Shenyang 110000,China.)

机构地区：[1]中国医科大学附属盛京医院泌尿外科,辽宁沈阳110000

出　　处：《现代肿瘤医学》2020年第10期1715-1718,共4页Journal of Modern Oncology

摘　　要：目的:评估同时行经尿道膀胱肿瘤切除(TURBT)及经尿道前列腺切除术(TURP)治疗的有症状的良性前列腺增生症(BPH)合并膀胱癌(BC)患者的安全性和生活质量(QOL)。方法:选取自2013年2月15日至2015年2月15日收入我院治疗的BC伴有症状的BPH患者共85例,其中观察组(第1组)42例和对照组(第2组)43例,观察组同期行TURBT、TURP,对照组行TURBT、口服坦索罗辛。两组患者术后均随访6~36个月。纳入标准为年龄≤75岁,首次诊断BC直径≤4 cm,前列腺体积≤80 ml。所有患者术前均用直肠指诊、前列腺特异性抗原(PSA)、最大尿流率(Qmax)和国际前列腺症状评分(IPSS)进行评估。术后随访IPSS、QOL、Qmax、肿瘤复发情况。结果:第1组平均复发时间为17.7个月,第2组平均复发时间为16.64个月。第1组总复发为22例,第2组为27例。第1组膀胱颈切缘/前列腺窝创面(BN/PU)复发为8例,第2组为9例。术后随访期间第1组QOL、IPSS和Qmax均优于第2组。结论:同时行TURBT和TURP在BN/PU复发率的比较无显著性差异(P>0.05),说明同期行TURBT、TURP在肿瘤学上是安全的,同时可以改善有症状的BPH并且需要手术的BC患者的QOL。Objective:To evaluate the oncological safety and quality of life(QOL)of symptomatic benign prostatic hyperplasia(BPH)patients with symptoms of bladder cancer(BC)treated with simultaneous transurethral resection of bladder tumor(TURBT)and transurethral prostatectomy(TURP).Methods:From February 15,2013 to February 15,2015,85 BPH patients with symptoms of BC were selected.42 patients in observation group(group 1)and 43 patients in control group(group 2).42 patients in observation group were treated with TURBT and TURP.43 patients in control group were treated with TURBT and tamsulosin.The two groups were followed up for 6 to 36 months after operation.The inclusion criteria were age less than 75 years old.For the first time,the diagnosis of BC was less than 4 cm,and the volume of prostate was less than 80 ml.All patients were evaluated by digital rectal examination,prostate specific antigen(PSA),maximal urinary flow rate(Qmax)and International Prostate Symptom Scale(IPSS).IPSS,QL,Qmax and tumor recurrence were followed up after operation.Results:The average recurrence time of the first groups was 17.7 months,and the average recurrence time of the second groups was 16.64 months.The total recurrence in the first groups was 22,and the second group was 27.The recurrence margin of the first group of bladder neck/prostatic urethra(BN/PU)was 8,and the second group was 9.The QOL,IPSS and Qmax of the first groups were better than those of the second group 12 months after operation.Conclusion:There was no significant difference between TURBT and TURP in the recurrence rate of BN/PU(P>0.05),indicating that TURBT and TURP are safe in oncology and can improve the QOL of symptomatic BPH patients who need surgery.

关 键 词：膀胱肿瘤 前列腺增生 经尿道前列腺切除术 经尿道膀胱肿瘤切除术 肿瘤复发 生活质量 

分 类 号：R737.14[医药卫生—肿瘤]