m^6A-RNA甲基化在正常造血和急性髓系白血病中的研究进展  

Research progress of m^6A-RNA methylation in normal hematopoiesis and acute myeloid leukemia

作　　者：张津京[1] 李艳[1] 张蕊[1] Zhang Jinjing;Li Yan;Zhang Rui(Department of Hematology,the First Affiliated Hospital of China Medical University,Liaoning Shenyang 110001,China)

机构地区：[1]中国医科大学附属第一医院血液科,辽宁沈阳110001

出　　处：《现代肿瘤医学》2020年第9期1568-1571,共4页Journal of Modern Oncology

基　　金：国家自然科学青年基金(编号:81600117)。

摘　　要：m^6A-RNA甲基化是一种类似于DNA甲基化或组蛋白修饰的表观遗传修饰方式。是由甲基化转移酶、去甲基转移酶和相关阅读蛋白共同调节的一种动态可逆的生物学过程,可以对mRNA产生不同的生物学作用,包括mRNA剪切、出核、降解、影响mRNA稳定性和翻译效率等。越来越多的研究表明m^6A-RNA甲基化在正常造血和急性髓系白血病中发挥重要的调控作用。本文就m^6A-RNA甲基化在正常造血和AML中的研究进展作一综述,旨在从表观转录组学层面深入了解AML的发病机制,为探索AML靶向治疗药物提供一种新的研究策略。m^6A-RNA methylation is considered as a kind of epigenetic modification similar to DNA methylation or histone modification.m^6A-RNA methylation is a dynamic and reversible process which is catalyzed by the m^6A methyltransferases,reverted by the demethylases and recognized by m^6A binding proteins.It can control biological function of mRNA by affecting RNA spicing,export,degradation,translation efficiency and stability.Recent studies show that,m^6A-RNA methylation has an important effect on normal hematopoiesis and participates in the pathogenesis of acute myeloid leukemia(AML).In this review,we mainly summarize the research progress of m^6A-RNA methylation in normal hematopoiesis and AML,in order to provide a new direction for both leukemogenesis and targeted therapy of AML.

关 键 词：m^6A-RNA甲基化 表观遗传修饰 急性髓系白血病 

分 类 号：R733.71[医药卫生—肿瘤]