门诊及长期住院的精神分裂症患者事件相关脑电位N400对照研究  

A control study of event related potentials N400 in outpatients and long-term inpatients with schizophrenia

作　　者：张莉 徐初琛 沈辉 ZHANG Li;XU Chu-chen;SHEN Hui(Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine Shanghai 201108,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心,201108

出　　处：《临床精神医学杂志》2020年第2期125-128,共4页Journal of Clinical Psychiatry

基　　金：上海交通大学医工交叉研究基金(YG2016QN43)。

摘　　要：目的:比较门诊及长期住院治疗的精神分裂症患者事件相关脑电位(ERPs)N400潜伏期及波幅。方法:采用汉语成语模式,对23例门诊精神分裂症患者(门诊患者组)、27例住院精神分裂症患者(住院患者组)进行N400检测,并与25名健康成人(正常对照组)比较。结果:与正常对照组比较,两患者组同音异形异义的匹配N400潜伏期显著延迟于对照组(P均<0.01);住院患者组异音形似异义匹配、异音异形同义非匹配以及异音异形异义非匹配N400潜伏期显著延迟(P<0.05或P<0.01);两患者组异音异形同义的匹配、非匹配的N400波幅明显降低(P<0.05或P<0.01);住院患者组同音异形异义匹配、同音异形异义非匹配、异音形似异义匹配的N400波幅明显降低(P<0.05或P<0.01)。与门诊患者组相比,住院患者组异音异形同义非匹配以及异音异形异义非匹配N400潜伏期显著延迟明显延迟(P<0.05或P<0.01);异音异形同义非匹配N400波幅明显降低(P<0.01)。结论:精神分裂症患者存在特异性的语言障碍;长期住院患者语言障碍更明显。Objective:To investigate the difference of latency and amplitude of event related potentials N400 in outpatients and long-term inpatients with schizophrenia.Method:Using Chinese idiom mode,N400 test was performed on 23 outpatients with schizophrenia(outpatient group),27 inpatients with schizophrenia(inpatient group)and 25 healthy adults(control group).Results:The congruent latencies of ending words with same pronunciation but different forms and meanings in both inpatients and outpatients with schizophrenia were significantly more than those in control group(P<0.01).The congruent latencies of ending words with different pronunciation and meanings and the incongruent latencies of ending words with different pronunciation and forms in inpatients were significantly more than those in control group(P<0.05 or P<0.01).The congruent and incongruent amplitudes of ending words with same meanings but different pronunciation and forms in schizophrenia were significantly lower than those in control group(P<0.05 or P<0.01).The congruent and incongruent amplitudes of ending words with same pronunciation but different forms and meanings and the congruent amplitudes of ending words with same forms but different pronunciation and meanings in inpatients were significantly lower than those in control group(P<0.05 or P<0.01).Compared with outpatients,the incongruent latencies of ending words with different pronunciation and forms in inpatients were significantly delayed.The incongruent amplitudes of ending words with same meanings but different pronunciation and forms in inpatients were significantly lower than outpatients(P<0.01).Conclusion:Patients with schizophrenia have specific language disorders.The speech impairment of long-term inpatients with schizophrenia were more obvious than outpatients.

关 键 词：精神分裂症 事件相关脑电位 N400 长期住院患者 门诊随访患者 

分 类 号：R749.3[医药卫生—神经病学与精神病学]