个体化护理对三维适形放疗联合阿瓦斯汀治疗结肠癌患者的疗效观察  

Observation on effect of individualized nursing on patients with three-dimensional conformal radiotherapy combined with avastin for treating colon cancer

作　　者：黑维琛 刘玥[1] 姜翠杰 马淑珍 HEI Weichen;LIU Yue;JIANG Cuijie;MA Shuzhen(Department of Oncology,Tianjin Municipal People′s Hospital,Tianjin 3991212,China)

机构地区：[1]天津市人民医院肿瘤科,300121

出　　处：《重庆医学》2020年第8期1237-1242,共6页Chongqing medicine

基　　金：国家自然科学基金面上项目(81573089);天津市卫生计生委科技基金项目(2015KZ061)。

摘　　要：目的探讨个体化护理应用于三维适形放疗联合阿瓦斯汀治疗结肠癌的应用效果。方法选取2017年10月至2018年10月在该院肿瘤内科行三维适形放疗联合阿瓦斯汀治疗的结肠癌患者82例,按照护理方式不同分为试验组和对照组,各41例。对照组给予常规治疗护理及教育指导,试验组在此基础上由专科护士全面评估,制订并实施个体化护理,比较两组患者治疗效果、不良反应发生率、治疗前后肿瘤标志物水平、生活质量和护理满意度等情况。结果试验组患者的总有效率为53.66%,明显高于对照组的31.71%(P<0.05);两组患者血清癌胚抗原(CEA)、糖链抗原199(CA199)、糖链抗原125(CA125)、甲胎蛋白(AFP)在T2(治疗结束后第1天)和T3(治疗结束后3个月)时间点均明显低于T1治疗前(P<0.05),且试验组较对照组下降幅度更为显著(P<0.05);试验组骨髓抑制、消化道反应、皮炎、放射性食管炎等不良反应的总发生率为14.63%较对照组的34.15%明显下降(P<0.05);两组患者生活质量和护理满意度在治疗前均差异无统计学意义(P>0.05),在治疗后试验组患者饮食控制、按时服药、社会功能及心理健康改善明显优于对照组(P<0.05),且试验组的总体护理满意度高于对照组(P<0.05)。结论针对结肠癌放化疗同步治疗的患者制订个体化护理程序并实施,将使患者极大地降低不良反应发生率,提高患者的治疗效果、护理满意度和生活质量。Objective To investigate the effect of individualized nursing application in three-dimensional conformal radiotherapy(3D-CRT)combined with avastin for treating colon cancer.Methods Eighty-two patients with colon cancer treated by three-dimensional conformal radiotherapy combined with avastin in the oncology department of this hospital from October 2017 to October 2018 were selected and divided into the experimental group and control group,41 cases in each group.The control group was given the routine treatment and education guidance.On this basis,the professional nurses in the experimental group conducted the comprehensive evaluation,formulated and implemented the individualized nursing.The treatment effect,occurrence rate of adverse reactions,tumor marker level,quality of life before and after treatment and nursing satisfaction were compared between the two groups.Results The total effective rate in the experimental group was 53.66%,which was significantly higher than 31.71%in the control group(P<0.05).The serum carcinoembryonic antigen(CEA),carbohydrate antigen 199(CA199),glycoprotein antigen 125(CA125),alpha-fetoprotein(AFP)at T2(on 1 d after treatment end)and T3(1n 3 months after treatment end)in the two groups were significantly lower than those at T1 before treatment(P<0.05),moreover the decrease amplitude in the experimental group was more significant than that in the control group(P<0.05).The total occurrence rate of bone marrow suppression,digestive tract reaction,dermatitis,radiation esophagitis,etc.in the experimental group was 14.63%,which was significantly decreased compared with 34.15%in the control group(P<0.05).There was no statistically significant difference in the quality of life and nursing satisfactionbefore treatment between the two groups(P>0.05).After treatment,the improvement in the aspects of the diet control,on-time taking medication,social function and mental health in the experimental group was significantly better than those in the control group(P<0.05),moreover the overall nursing s

关 键 词：结肠癌 三维适形放疗 个体化护理 阿瓦斯汀 

分 类 号：R735.35[医药卫生—肿瘤]