胞外HMGB1在常见眼科疾病中的研究进展  

Research progress of extracellular high mobility group box 1 in common ophthalmic diseases

作　　者：周永莹 李轩[1,2] Yong-Ying Zhou;Xuan Li(Clinical College of Ophthalmology,Tianjin Medical University,Tianjin 300020,China;Tianjin Eye Hospital,Tianjin Eye Institute,Tianjin Key Laboratory of Ophthalmology and Visual Science,Tianjin 300020,China)

机构地区：[1]天津医科大学眼科临床学院,中国天津市300020 [2]中国天津市眼科医院,天津市眼科研究所,天津市眼科学与视觉科学重点实验室,300020

出　　处：《国际眼科杂志》2020年第5期813-817,共5页International Eye Science

基　　金：国家自然科学基金资助项目(No.81170828,81670837);天津市应用基础与前沿技术研究计划项目(No.15JCZDJC35300);天津市卫计委科技攻关项目(No.14KG133)。

摘　　要：高迁移率蛋白家族(high mobility group box,HMGB)因其在电泳中的高迁移率而得名,其中对高迁移率蛋白1(high mobility group box 1,HMGB1)的研究最为深入。研究表明,胞外HMGB1作为损伤相关分子模式(damage-associated molecular pattern,DAMP)参与多种常见眼部疾病——干眼、角膜病、青光眼、葡萄膜炎、糖尿病性视网膜病变、年龄相关性黄斑变性的组织损伤修复的病理生理过程,从而对疾病的愈合产生负性影响。沉默胞外HMGB1的功能有望成为这些眼科疾病新的治疗手段。本文就胞外HMGB1在常见眼科疾病中的研究进展作一综述。·High mobility group box 1(HMGB1),which belongs to a high mobility group box that known for high mobility in electrophoresis,has been researching most intensively.Recently,researches have revealed that extracellular HMGB1,as a damage-associated molecular pattern(DAMP),is involved in the pathophysiology of tissue damage repairin a variety of common ocular diseases,namely,dry eye,keratopathy,glaucoma,uveitis,diabetic retinopathy,and age-related macular degeneration,thereby negatively affecting the healing of the disease.Silencing the function of extracellular HMGB1 is expected to be a new way for these ophthalmic diseases.This thesis reviews the research progress of extracellular HMGB1 in common ophthalmic diseases.

关 键 词：HMGB1 炎症反应 免疫学 DAMP 

分 类 号：R73[医药卫生—肿瘤]