急性脑梗死中医证型与NT-proBNP、UA、Hcy、Fib的相关性分析  

Analysis of Correlation among TCM Syndromes of Acute Cerebral Infarction,NT-proBNP,UA,Hcy and Fib

作　　者：陈景利 梁文倩 何明丰 袁康 李旷怡 张英俭 李莹莹 刘宝华 Chen Jingli;Liang Wenqian;He Mingfeng;Yuan Kang;Li Kuangyi;Zhang Yingjian;Li Yingying;Liu Baohua(Foshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine,Guangdong,Foshan 528000,China)

机构地区：[1]广州中医大学附属佛山中医院,广东佛山528000

出　　处：《中国中医急症》2020年第4期624-626,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：广东省科技厅社会发展项目(2014A020212002);广东省佛山市科技局医学类科技攻关项目(2015AB00355、2016AB002571、2017AB002151、2017AB002141、1920001001102);广东省佛山市科技局科技创新平台项目(2015AG10001、2017AG100061、2017AG100082);广东省佛山市重点专科培育项目(Fspy2-2015004);广东省佛山市十三五高水平重点专科建设项目(FSGSSPZD135025);2018年广东省教育厅临床教学基地教学改革研究项目(2017JD071);广东省科技厅社会发展项目2014AB00328);佛山市科技局项目(2014AG10002、2017AB002651)。

摘　　要：目的探讨急性脑梗死中医证型与氨基末端B型钠尿肽前体(NT-proBNP)、尿酸(UA)、同型半胱氨酸(Hcy)、纤维蛋白原(Fib)的相关性并探讨其机制。方法纳入2017年6月1日至2019年1月20日本院收治的第一诊断为急性脑梗死患者共200例,根据标准对入院患者进行中医辨证分型,并对患者进行NT-proBNP、UA、Hcy、Fib统计分析。结果急性脑梗死中脏腑与NT-proBNP有一定的相关性(P<0.05),通过Logistics回归分析,中脏腑组的NT-proBNP水平较非中脏腑组高9.142倍,且差异有统计学意义(P<0.05)。UA、HCY、Fib水平与急性脑梗死各中医证型之间无明显相关性(P>0.05)。结论急性脑梗死中脏腑与NT-proBNP之间有一定的相关性,UA、Hcy、Fib与急性脑梗死中医证型无明显相关性。Objective:To explore the correlation among TCM syndromes of acute cerebral infarction,NT-proBNP,UA,Hcy and Fib.Methods:200 patients,fron June 1st,2017 to January 20th,2019 were classified according to TCM syndrome differentiation.NT-proBNP,UA,Hcy and Fib were analyzed.Results:There was a certain correlation between the viscera and NT-proBNP in acute cerebral infarction(P<0.05).By Logistic regression analysis,the NT-proBNP level in the viscera group was 9.142 times higher than that in the non-viscera group,and the difference was statistically significant(P<0.05).There was no significant correlation between UA,HCY,Fib levels and TCM syndromes of acute cerebral infarction(P>0.05).Conclusion:There is a certain correlation between the viscera and NT-proBNP in acute cerebral infarction.UA,Hcy and Fib have no obvious correlation with TCM syndromes of acute cerebral infarction.

关 键 词：急性脑梗死 中医证型 氨基末端B型钠尿肽前体 尿酸 同型半胱氨酸 纤维蛋白原 

分 类 号：R743.3[医药卫生—神经病学与精神病学]