体内脂质过氧化水平的影响因素  

The influencing factors of lipid peroxidation in the body

作　　者：徐瑫 曹丽敏[1] 周敏 陈卫红[1] XU Tao;CAO Limin;ZHOU Min;CHEN Weihong(Department of Occupational and Environmental Health,Key Laboratory of Environment and Health,Ministry of Education&Ministry of Environmental Protection,and State Key Laboratory of Environmental Health(Incubating),School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院公共卫生学院劳动卫生与环境卫生学系,环境与健康教育部重点实验室,国家环境保护部环境与健康重点实验室,武汉430030

出　　处：《公共卫生与预防医学》2020年第2期122-125,共4页Journal of Public Health and Preventive Medicine

基　　金：国家自然科学基金(91543207,91843302)。

摘　　要：脂质过氧化是一种常见的氧化损伤类型,参与多种疾病的病理进程,许多因素均可影响体内脂质过氧化的水平。此文汇总了近年来国内外人群流行病学资料,分别从个体因素(年龄、性别、体重指数)、生活方式(吸烟、饮酒、体育锻炼等)、环境因素方面综述其对脂质过氧化标志物的影响。研究内容显示,不同个体因素对体内脂质过氧化物的影响尚存在争议;吸烟、饮酒等生活方式和来自室内外的空气污染均是升高脂质过氧化水平的危险因素,而规律性体育锻炼则是降低脂质过氧化的保护因素。更多的流行病学证据和深入的机制研究亟待开展以更好认识脂质过氧化的影响因素及其在疾病发生发展中的作用,从而实现慢性病的早期预防。Lipid peroxidation is a common type of oxidative damage and is involved in the pathological process of numerous diseases.Many factors can affect the levels of lipid peroxidation in the body.This paper summarizes the epidemiological studies in recent years,and presents the impact of individual(age,gender and body mass index),lifestyle(smoking,drinking and physical activity)and environmental factors on lipid peroxidation.The research results suggest that the impact of different individual factors on lipid peroxidation in the body is still controversial.Lifestyles such as smoking and drinking,and air pollution from both indoors and outdoors may be risk factors increasing the levels of lipid peroxidation,while regular physical exercise might be a protective factor decreasing the levels of lipid peroxidation.More epidemiological evidence and in-depth mechanism studies are urgently needed to better understand the influencing factors of lipid peroxidation and its role in the occurrence and development of diseases,so as to achieve early prevention of chronic diseases.

关 键 词：脂质过氧化 生活方式 空气污染 慢性病 

分 类 号：R153[医药卫生—营养与食品卫生学]