急性脑桥梗死继发不宁腿综合征4例报道并文献复习  

Restless leg syndrome secondary to acute pontine infarction: four cases report and literature review

作　　者：石国美 徐武[1] 汪小荣[1] 路敬叶[1] 李妍 周汝娟[1] Shi Guomei;Xu Wu;Wang Xiaorong(Department of Neurology,The People's Hospital of Taixing,Taixing Jiangsu 225400)

机构地区：[1]江苏省泰兴市人民医院神经内科,225400

出　　处：《卒中与神经疾病》2020年第1期60-64,共5页Stroke and Nervous Diseases

基　　金：泰兴市人民医院2018年度院级基金科研课题(编号try1806)。

摘　　要：目的探讨急性脑桥梗死继发不宁腿综合征(RLS)的临床表现、发病机制、诊断及治疗。方法回顾性分析4例脑桥梗死继发RLS患者的临床资料,分析临床表现和治疗过程,总结临床特征并进行文献复习。结果 4例患者均急性起病,有神经功能缺损的体征,明确诊断为急性脑桥梗死,在脑桥梗死后0~3 d出现单侧或双侧肢体不适感,需活动肢体以减轻不适,其中3例予吡贝地尔缓释片口服后肢体不适症状消失。结论脑桥梗死是继发性RLS的非常见病因,易漏诊,其发病机制有待于进一步研究,钙通道α2δ配体和多巴胺受体激动剂是一线治疗方案,该病早期诊治预后良好。Objective To investigate the clinical presentations, pathogenesis, diagnosis and treatment of restless leg syndrome secondary to acute pontine infarction. Methods The clinical data of 4 patients with restless leg syndrome secondary to acute pontine infarction were analyzed retrospectively. The related literature were reviewed and the clinical features were summarized. Results The 4 patients presented with acute onset, with the symptoms of neurological impairment, cranial MRI showed pontine infarction. The symptoms of an urge to move the limbs associated with unpleasant sensations occured 0~3 days after the onset of stroke. Oral administration of piribedil showed an efficacy for the treatment of stroke-related restless leg syndrome. Conclusion Restless leg syndrome secondary to acute pontine infarction was a relatively uncommon condition. Dopamine agonists and α2δ ligands were suggested as first-line treatment. The earlier diagnosis were helpful to favorable prognosis.

关 键 词：脑桥梗死 不宁腿综合征 发病机制 多巴胺能药物 钙通道α2δ配体 

分 类 号：R743.3[医药卫生—神经病学与精神病学]