尼古丁加重渗出型老年性黄斑变性脉络膜新生血管形成的研究现状  

Research status of nicotine-aggravating the choroidal neovascularization formation in wet age-related macular degeneration

作　　者：巩亚军 赖坤贝[1] 金陈进[1] Gong Yajun;Lai Kunbei;Jin Chenjin(State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangzhou 510060,China)

机构地区：[1]中山大学中山眼科中心,眼科学国家重点实验室,广州510060

出　　处：《中华眼底病杂志》2020年第4期319-322,共4页Chinese Journal of Ocular Fundus Diseases

基　　金：国家自然科学基金(81670866、81600741)。

摘　　要：脉络膜新生血管(CNV)是导致渗出型老年性黄斑变性(wAMD)患者中心视力丧失的主要原因。吸烟不仅增加wAMD患者CNV发生率,还加重wAMD患者病情,使其临床治疗效果及预后更差。尼古丁作为烟草中的重要有害物质,是一种易成瘾且高毒性的生物碱。动物实验和临床研究均证实,尼古丁可通过烟碱型乙酰胆碱受体、骨髓原始细胞、炎症、补体系统等介导血管生成,加重wAMD。积极探讨尼古丁加重wAMD CNV形成的确切机制,有助于早期采取相应干预措施来预防或延缓其发展。Choroidal neovascularization is the leading causes of central vision loss in wet age-related macular degeneration(wAMD)patients.Smoking not only aggravates the incidence and severity of the choroidal neovascularization of wAMD,but also affects the clinical treatment,making the prognosis worse.Nicotine,as an important harmful substance in tobacco,is an easily addictive and highly toxic alkaloid.Animal experiments and clinical studies have confirmed that nicotine can aggravate wAMD by mediating angiogenesis through nicotinic acetylcholine receptor,bone marrow blasts,inflammation,complement system,etc.Therefore,in order to early take appropriate intervention measures to prevent and delay the development,we should actively explore the exact pathogenesis by which nicotine aggravates the choroidal neovascularization.

关 键 词：湿性黄斑变性/病因学 脉络膜新生血管化/病因学 尼古丁 综述 

分 类 号：R77[医药卫生—眼科]