腓骨肌萎缩症患者的神经电生理分析  

Electroneurophysiological characteristics analysis in patients with Charcot-Marie-Tooth disease

作　　者：刘磊[1] 韩雁冰[1] 单灵敏 LIU Lei;HAN Yanbing;SHAN Lingmin(Department of Neurology,the First Affiliated Hospital of Kunming Medical University,Kunming,650032,Yunnan,China)

机构地区：[1]昆明医科大学附一院神经内科,云南昆明650032 [2]云南省第二人民医院康复科

出　　处：《癫痫与神经电生理学杂志》2020年第2期76-80,共5页Journal of Epileptology and Electroneurophysiology(China)

基　　金：云南省人才培养项目(NO:2017HB048,D-201623)。

摘　　要：目的:分析腓骨肌萎缩症(CMT)患者临床及神经电生理改变的特点。方法:回顾18例CMT 1型患者的四肢运动神经传导速度(MCV)、感觉神经传导速度(SCV).F波及肌电图(EMG)的改变,并对检查结果进行分析。结果:所检18例临床已经确诊的CMT 1型患者中男性多于女性,双下肢或四肢均出现远端对称性肌无力及肌萎缩,有普遍的神经传导速度显著下降,甚至引不出电位。MCV和SCV远端潜伏期延长,但肌肉复合动作电位(CMAP)和感觉神经动作电位(SNAP)的波幅正常或降低。双正中神经及双胫神经F波的潜伏期及出现率均表现异常,所检肌肉呈慢性神经原性损伤。结论:神经电生理检查对于该病的分型和预后都有一定的评估作用,对于家族史不明确、病程隐匿的患者,神经电生理检查可为临床提供准确而可靠的诊断依据。Objective:To study the clinical and electroneurophysiological characteristics in patients with charcot-marie-tooth(CMT).Method:The variation trend of motor nerve conduction velocity(MCV).sensory nerve conduction velocity(SCV),F waves and electromyography(EMG)of 18 cases were examined and analyzed.Result:Among the 18 cases,more male patients with CMT were found than female,and the symptoms were characterized by muscular atrophy and symmertric muscular weakness of dual lower limbs or all limbs,generally and remarkably reduced nerve conduction velocities,and no potential introduced.The incubations of MCV and SCV were prolonged.while the amplitudes were maintained or decreased.And the F waves of double median nerves and double tibial nerves were abnormal in incubation and occurence.Every detected muscules were comfirmed as neurogenic chronic injury.Conclusion:Electroneurophysiological examination can evaluate the classification and prognosis of the disease.Its necessary for patients with CMT,especially for those who are unclear about the familial medial history nnd personal medical history or hide personal medical history,to check nervous electrophysilogical behaviors in early stage,offering reliable diagnostic basis for clinic effects.

关 键 词：腓骨肌萎缩症(CMT):神经传导速度 F波 肌电图学 神经电生理学 

分 类 号：R746.4[医药卫生—神经病学与精神病学] R741.044[医药卫生—临床医学]