240例胰腺癌肝转移临床特征及预后分析  

Analysis of clinicopathological features of 240 cases of pancreatic cancer with liver metastasis and prognostic risk factors

作　　者：李宣娜 陈尚祥 练国达[1] 陈少杰[1] 黄开红[1] LI Xuan-na;CHEN Shang-xiang;LIAN Guo-da;CHEN Shao-jie;HUANG Kai-hong(Department of Gastroenterology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,China)

机构地区：[1]中山大学孙逸仙纪念医院消化内科,广州510120

出　　处：《岭南现代临床外科》2020年第2期151-154,160,共5页Lingnan Modern Clinics in Surgery

基　　金：国家自然科学基金面上项目(81572396,81874057);广东省自然科学基金博士科研启动项目(2018A030310227);中央高校基本科研业务费资助项目(18zxxt59);广东省医学科学技术研究基金项目(A2018012)。

摘　　要：目的研究胰腺导管腺癌(PDAC)肝转移患者临床与病理特征,并分析影响患者预后危险因素。方法回顾性分析2007年1月至2014年10月中山大学孙逸仙纪念医院具有完整临床病理资料PDAC肝转移病例共240例,并随访本组患者。采用Kaplan-Meier统计学方法评估患者生存情况,并用Cox单因素分析、多因素回归模型筛选影响患者预后的独立危险因素。结果在纳入本研究患者中,截至随访终点,共有227名患者死亡(94.58%),中位生存时间为5.34月。6个月,1年,3年生存率分别为36.50%、16.36%和5.39%。单因素生存分析提示年龄、CA19-9、肿瘤分化程度、T分期、化疗为预后危险因素。多因素分析显示T4分期、肿瘤低分化、未接受化疗为胰腺癌肝转移患者预后独立危险因素。结论T4分期、肿瘤低分化程度、未接受化疗为胰腺癌肝转移患者预后独立危险因素。Objective To analyze the clinical and pathological characteristics of patients with pancre-atic ductal adenocarcinoma(PDAC)liver metastasis,and to identify independent prognostic risk factors.Methods A total of 240 cases of PDAC liver metastasis patients from Sun Yat-sen Memorial Hospital,Sun Yat-sen University were included in the study.The patients,who were hospitalized during January 2007 to October 2014,were recorded full clinicopathological data.Kaplan-Meier was used to evaluate the survival of patients.Cox univariate analysis and multivariate regression model were used to identify inde-pendent prognostic risk factors.Results At the end of the follow-up,227 patients died(94.58%),and the overall median survival time was 5.34 months.The 6-month,1-year,and 3-year survival rates were 36.50%,16.36%,and 5.39%,respectively.Univariate survival analysis suggested that age,CA19-9,tu-mor differentiation,T stage,and chemotherapy were prognosis risk factors.Multivariate analysis implied that T4 stage,poorly differentiated tumor,and not receiving chemotherapy were independent risk factors for prognosis.Conclusion T stage,tumor differentiation,and chemotherapy are independent prognostic risk factors for patients with PDAC liver metastasis.

关 键 词：胰腺癌 临床资料 预后 危险因素 

分 类 号：R735.9[医药卫生—肿瘤]