前列腺癌并阴茎转移综合治疗一例报告并文献复习  

Comprehensive treatment of prostate cancer with penis metastasis:a case report and literature review

作　　者：张中元[1] 白杲琛 虞巍[1] 何群[1] 宋毅[1] 金杰[1] Zhang Zhongyuan;Bai Gaochen;Yu Wei;He Qun;Song Yi;Jin Jie(Department of Urology,Peking University First Hospital,Institute of Urology,Peking University,National Urological Cancer Center,Beijing 100034,China)

机构地区：[1]北京大学第一医院泌尿外科,北京大学泌尿外科研究所,国家泌尿、男性生殖系肿瘤研究中心,100034

出　　处：《中华临床医师杂志（电子版）》2020年第3期217-221,共5页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的探讨前列腺癌并阴茎转移的发病机制、临床特征及诊疗预后。方法回顾性分析1例前列腺癌并阴茎转移患者的临床资料。结果患者68岁,因排尿困难在我院行经尿道前列腺电切术,术后病理检查报告为前列腺腺癌。术后行外放射治疗及内分泌治疗,15个月后发生阴茎转移,予以个体化的治疗方案后前列腺癌特异性抗原下降,阴茎肿块缩小,不适症状缓解。结论前列腺癌阴茎转移发生罕见且预后差,有多种转移机制参与;手术及放化疗虽为姑息性治疗,但个体化的治疗方案可延缓疾病进展,改善患者生活质量。Objective To explore the pathogenesis,clinical features,prognosis and treatment of prostate cancer with penile metastasis.Methods The clinical data of a patient with prostate cancer and penis metastasis were retrospectively analyzed.Results A 68-year-old man underwent transurethral resection of the prostate due to dysuria at our hospital,and the postoperative pathological examination revealed prostate adenocarcinoma.Fifteen months later,penis metastasis occurred.After treatment with external radiotherapy and endocrine therapy,prostate-cancer specific antigen decreased,the penis mass shrank,and the discomfort symptoms resolved.Conclusion Penile metastasis of prostate cancer is rare and has a poor prognosis.Although surgery,radiotherapy,and chemotherapy are palliative treatment,individualized treatment can delay disease progression and improve the quality of life.

关 键 词：前列腺癌 阴茎转移癌 放疗 化疗 肿瘤转移 

分 类 号：R737.25[医药卫生—肿瘤]