含硅二烃基锡(Ⅳ)水杨醛缩氨基硫脲席夫碱配合物的合成、结构及抗癌活性  

Synthesis,Structure and Antitumour Activity of Diorganotin(Ⅳ)Complexes Containing Silicon of Salicylaldehyde Thiosemicarbazone

作　　者：谢波 姚华 廖启华 邓瑞红 林森 严兆华 XIE Bo;YAO Hua;LIAO Qi-Hua;DENG Rui-Hong;LIN Sen;YAN Zhao-Hua(College of Chemistry,Nanchang University,Nanchang 330031,China)

机构地区：[1]南昌大学化学学院,南昌330031

出　　处：《无机化学学报》2020年第5期819-826,共8页Chinese Journal of Inorganic Chemistry

摘　　要：合成了11个含硅二烃基锡的水杨醛缩氨基硫脲席夫碱配合物R(Me3SiCH2)SnL(R=Me3SiCH2或Ph,Cy;H2L=水杨醛缩氨基硫脲席夫碱),并通过1H NMR、13C NMR、IR、元素分析和X射线单晶衍射对目标化合物结构进行了表征。结果表明,水杨醛缩氨基硫脲席夫碱作为三齿双阴离子配体,通过酚氧、亚胺氮和硫醇硫与锡(Ⅳ)配位,形成了中心锡原子为五配位的五元杂环与六元杂环的并联结构。生物活性试验的初步结果显示,该类化合物对人体乳腺癌细胞MDA-MB-231和MCF-7具有较好的体外抗癌活性。Eleven diorganotins containing silicon of salicylaldehyde thiosemicarbazone were synthesized and characterized through 1 H NMR,13C NMR,IR spectra,elemental analysis and X-ray single crystal diffraction tests.The result shows that the thiosemicarbazone Schiff base coordinates with tin atom as tridentate dianionic ligand through thephenolic oxygen,imine nitrogen and mercaptan sulfur,forming a parallel five and six-member heterocyclic structures.The preliminary bioassay result shows that these compounds have a good antitumor activity in vitro against MDA-MB-231 and MCF-7.CCDC:1060109,3 ab;1041385,3 db;1032939,3 dc.

关 键 词：二烃基锡 缩氨基硫脲 席夫碱 合成 结构 生物活性 

分 类 号：O614.431[理学—无机化学]