A highly efficient In(OTf)3-catalyzed[3+3]annulation of spirocyclopropyl oxindoles with 1,4-di-thiane-2,5-diol  

作　　者：Yongjia Hao Yi Gong Zhongyan Cao Ying Zhou Jian Zhou 

机构地区：[1]School of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guiyang 550025,China [2]Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development,East China Normal University,Shanghai 200062,China

出　　处：《Chinese Chemical Letters》2020年第3期681-684,共4页中国化学快报（英文版）

基　　金：financial support from the National Natural Science Foundation of China(No.81660576);the Project of Guizhou Province Qian Ke He GZ[2015]4001;Guizhou Discipline Construction Project(No.GNYL[2017]008)。

摘　　要：Spirooxindoles play an important role in drug discove ry and development.The development of efficient methods for the synthesis of spirooxindoles from easily available sta rting materials is of curre nt interest Herein,we report in detail the In(OTf)3-catalyzed[3+3]annulation of spirocyclopropyl oxindoles and 1,4-di-thiane-2,5-diol,which allows the facile preparation of spiro[indoline-3,4'-thiopyran]-2-ones bearing(tetrahydro)thiopyran skeleton.

关 键 词：SPIROOXINDOLES Lewis acid catalysis [3+3]cycloaddition Sulfur HETEROCYCLES CYCLOPROPANE 

分 类 号：O626[理学—有机化学] TQ463.5[理学—化学]