氟比洛芬酯在鲜红斑痣血卟啉单甲醚光动力疗法中镇痛效果的临床初步观察  

Analgesic Effect of Flurbiprofen Ester in Hematoporphyrin Monomethyl Ether-mediated Photodynamic Therapy for Port-Wine Stains:Preliminary Clinical Observations

作　　者：周俊 刘晶[1] 胡蝶[1] 曾维惠[1] 崔鹿 葛文娱[1] 王晓鹏[1] ZHOU Jun;LIU Jing;HU Die;ZENG Weihui;CUI Lu;GE Wenyu;WANG Xiaopeng(Department of Dermatology,the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,China)

机构地区：[1]西安交通大学第二附属医院皮肤病院,陕西西安710004

出　　处：《中国皮肤性病学杂志》2020年第5期534-537,共4页The Chinese Journal of Dermatovenereology

摘　　要：目的观察氟比洛芬酯在鲜红斑痣血卟啉单甲醚光动力治疗过程中的镇痛效果。方法选择门诊大面积运用光动力治疗的面颈部鲜红斑痣成人患者20例,年龄18~30岁。第一次光动力治疗时不使用镇痛药物,术后5 min让患者用数字评分法对术中疼痛程度进行自我评估;第二次治疗前20 min静滴氟比洛芬酯注射液50 mg,术后5 min让患者再次评估术中疼痛程度。每次治疗后2个月对单次的疗效再进行评估。结果第二次治疗组(氟比洛芬酯组)疼痛评分低于第一次治疗组(对照组)的疼痛评分,差异具有统计学意义(P<0.001);两组治疗的单次疗效差异无统计学意义(P>0.05)。结论氟比洛芬酯用于鲜红斑痣血卟啉单甲醚光动力疗法的镇痛是安全有效的。Objective To observe the analgesic effect of flurbiprofen ester in hematoporphyrin monomethyl ether-mediated photodynamic therapy in the treatment of port-wine stain(nevus flammeus).Methods Twenty adult patients with nevus flammeus on the large area of face and neck treated by photodynamic therapy were selected.No analgesics were used in the first photodynamic therapy.The patients were asked to self-evaluate the intraoperative pain degree by digital scoring method 5 minutes after the operation.The patients were given 50 mg flurbiprofen ester injection 20 minutes before the second treatment,and were asked to re-evaluate the intraoperative pain degree 5 minutes after the operation.The efficacy of a single treatment was evaluated 2 months after each treatment.Results The pain score of the second treatment group(flurbiprofen ester group)was lower than that of the first treatment group(control group);the difference was statistically significant(P<0.001).There was no statistical difference in the treatment efficacy between the two groups(P>0.05).Conclusion Flurbiprofen ester is safe and effective for analgesia in hematoporphyrin monomethyl ether-mediated photodynamic therapy for nevus flammeus.

关 键 词：光动力疗法 氟比洛芬酯 镇痛 血卟啉单甲醚 

分 类 号：R739.5[医药卫生—肿瘤]