近红外荧光探针用于阿尔茨海默病标志物检测的研究进展  

Advances of near-infrared fluorescent probes for detection of Alzheimer′s disease

作　　者：葛亦然 杨剑[1] 李玉艳[1] 徐云根[1] GE Yiran;YANG Jian;LI Yuyan;XU Yungen(Department of Medicinal Chemistry,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学药物化学系,南京211198

出　　处：《中国药科大学学报》2020年第2期138-151,共14页Journal of China Pharmaceutical University

基　　金：博士后科学基金第62批面上资助项目(No.1600010008);中国药科大学“双一流”创新团队项目资助(No.CPU2018GY20)。

摘　　要：阿尔茨海默病(Alzheimer′s disease,AD)是一种多发于老年人的神经退行性疾病,目前尚无有效治疗方法。随着近年来多个AD治疗药物在临床Ⅲ期实验中遭遇失败,全世界逐渐把目光投向AD早期诊断技术的开发。近红外荧光(near-infrared fluorescence,NIRF)分子探针技术在AD大脑生物标志物检测技术开发中具有独特的优势,是当下AD早期诊断技术研究的重要领域。本文对用于标记β-淀粉样蛋白、Tau蛋白及活性氧簇的近红外荧光小分子探针的研究进展进行了全面的总结分析,包括各类近红外分子探针的化学结构、光学性质、体外以及体内实验,并对AD的诊断发展提出了新的方向。相信这些新的思路对近红外小分子探针在AD领域的研究有着重要的意义。Alzheimer′s disease(AD)is a chronic neurodegenerative diseasecommonly seen in the elderlys.Several therapeutic drugs have failed in phase III clinical trials in recent years and there have been no efficient treatment for AD currently.Thus,there has been an urgent need for the effective methods of AD diagnosis at early stage.Developingnear-infrared fluorescentprobes for AD hallmarks detection has been a promising research field.In this review,we summarized a variety of near-infrared fluorescence(NIRF)probes reported in the past decade,which capable of detectingβ-amyloid,Tau protein and reactive oxygen species,including their chemical strucutres、optical properties,in vitro and in vivo studies.Furthermore,we alsoraised some new directions for AD diagnosing.We believe that these new directions raised herein will benefit the future development of NIRF probes in the field of AD research.

关 键 词：阿尔茨海默病 早期诊断 近红外荧光 探针 Β-淀粉样蛋白 TAU蛋白 活性氧簇 

分 类 号：R749[医药卫生—神经病学与精神病学]