纳米碳混悬液作图法在乳腺癌新辅助化疗后腋窝淋巴结清扫中检出数目及腋窝微小淋巴结检出数目中的临床优势  

The clinical advantage of nano carbon suspension mapping in the number of axillary lymph nodes detected after neoadjuvant chemotherapy for breast cancer

作　　者：牟鳄贤 张蒲蓉[1] 张剑辉[1] 刘世伟 夏莉[1] 王浩[1] Mu Exian;Zhang Purong;Zhang Jianhui;Liu Shiwei;Xia Li;Wang Hao(Breast Surgery Center of Sichuan Cancer Hospital,Chengdu 610041,China)

机构地区：[1]四川省肿瘤医院乳腺外科中心,成都610041

出　　处：《中国综合临床》2020年第2期118-120,共3页Clinical Medicine of China

摘　　要：目的对比纳米碳混悬液作图法与无染料法在乳腺癌新辅助化疗后腋窝淋巴结清扫中淋巴结检出数目及腋窝微小淋巴结检出数目中的效果。方法选择四川省肿瘤医院乳腺外科2018年1月1日至2018年7月1日经新辅助治疗后拟接受腋窝淋巴结清扫手术的乳腺癌患者66例,行前瞻性研究。采用随机数字表法随机分为纳米碳作图法组(33例)和对照组(33例),分别使用术前24 h皮下注射纳米碳后再行腋窝淋巴结清扫与不使用染料直接行腋窝淋巴结清扫两种方法,统计两组患者腋窝淋巴结检出数目及腋窝微小淋巴结检出数目情况。结果纳米碳作图法组腋窝淋巴结检出数目及微小淋巴结检出数目均高于对照组,差异均有统计学意义[腋窝淋巴结数目:(19.3±6.2)枚与(14.9±6.7)枚,P=0.007;腋窝微小淋巴结数目:2.0(0.5,3.0)枚与0(0,1.0)枚,Z=-4.328,P<0.001]。结论纳米碳混悬液作图法可以增加乳腺癌新辅助化疗后腋窝淋巴结清扫中淋巴结检出数目,同时对一些不易发现的腋窝微小淋巴结的检出也具有优势。Objective To compare the advantages of nano carbon suspension mapping method and non dye method in the number of axillary lymph nodes detected during axillary lymph node dissection and axillary micro lymph nodes detected after neoadjuvant chemotherapy for breast cancer.Methods From January 1st,2018 to July 1st,2018,66 breast cancer patients who were to undergo axillary lymph node dissection after new adjuvant treatment were selected for the prospective study.Using the method of random number table,the patients were randomly divided into two groups:the group of nano carbon mapping(33 cases)and the control group(33 cases).After 24 hours subcutaneous injection of nano carbon before operation,axillary lymph node dissection and direct axillary lymph node dissection without dye were used.The number of axillary lymph nodes and the number of micro axillary lymph nodes in the two groups were observed.Results The number of axillary lymph nodes and micro lymph nodes in the nano carbon mapping group were higher than those in the control group.The differences were statistically significant(the number of axillary lymph nodes were(19.3±6.2)vs(14.9±6.7),P=0.007;the number of micro-lymph nodes were 2.0(0.5,3.0)vs 0(0,1.0),Z=-4.328,P<0.001).Conclusion Nano carbon suspension mapping can increase the number of lymph nodes detected in axillary lymph node dissection after neoadjuvant chemotherapy for breast cancer,and also has advantages in the detection of some small axillary lymph nodes that are not easy to find.

关 键 词：乳腺癌 纳米碳混悬液 腋窝淋巴结清扫 微小淋巴结 新辅助化疗 

分 类 号：R737[医药卫生—肿瘤]