独立通风笼具(IVC)技术指标检测及参数稳定性评价  

Detection and stability evaluation of technical parameters of individually ventilated cages

作　　者：闵凡贵[1] 王静[1] 潘金春[1] 黄树武[1] 龚宝勇[1] 张钰[1] MIN Fangui;WANG Jing;PAN Jinchun;HUANG Shuwu;GONG Baoyong;ZHANG Yu(Guangdong Laboratory Animals Monitoring Institute,Guangdong Provincial Key Laboratory of Laboratory Animals,Guangzhou 510663,China)

机构地区：[1]广东省实验动物监测所,广东省实验动物重点实验室,广州510663

出　　处：《中国比较医学杂志》2020年第4期106-109,共4页Chinese Journal of Comparative Medicine

基　　金：广东省科技计划项目(2018B070714012)。

摘　　要：目的探讨IVC技术指标的检测方法并评价IVC参数的稳定性。方法依据GB 14925-2010与DB32/T 972-2006标准规定的方法,对摆放在普通环境和屏障环境的IVC进行检测,分析IVC微环境对外环境技术指标的依赖程度,比较不同换气次数测定方法的差异,并计算各指标的相对偏差和笼盒泄漏率。结果IVC微环境的温度、湿度与外环境参数正相关;依据GB14925-2010附录方法测定的笼盒内换气次数明显高于流量计法的测定值(t-test,P=0.0001);IVC笼架对角线上5个笼盒的换气次数、噪声、风速的相对偏差较小,但静压差的相对偏差较大;IVC笼盒泄漏率检测结果高达75%。结论IVC的使用受制于外环境条件,笼架不同位置的笼盒内静压差的稳定性差,与较高的笼盒泄漏率相关,研究结果可为IVC国家或行业准制(修)订提供参考。Objective To study method for testing the technical parameters of individually ventilated cages(IVCs)and evaluating the stability of IVC parameters.Methods In accordance with the method of GB 14925-2010 and DB32/T 972-2006,IVCs that were placed in the conventional and barrier environments were tested respectively.Correlations between the micro-and macro-environments were analyzed.Two method for testing air changes per hour(ACH)were compared.The relative deviation(based on 5 diagonal cages)of IVC and cage leakage rates were also calculated.Results The temperature and humidity of the micro-environment were positively correlated with those of the macro-environment.The ACH was significantly higher when tested using the method of GB 14925-2010 compared with using the flowmeter method.The relative deviations of ACH,noise,and airflow velocity were smaller than that of the hydrostatic pressure difference.Cage leakage rates were high,at 75%.Conclusions Use of IVCs was limited to the macro-environment.The hydrostatic pressure difference showed a low stability,which was correlated with cage leakage rates.The result of this study provide a reference for formulating national or trade standards.

关 键 词：IVC 技术指标检测 相对偏差 泄漏率 

分 类 号：R-33[医药卫生]