细胞焦亡与癫痫  

Pyroptosis and epilepsy

作　　者：孙立超[1] 朱战鹏[2] 李薇[1] 林卫红[3] SUN Li-chao;ZHU Zhan-peng;LI Wei(Department of Emergency Medicine,the First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学第一医院急诊内科,长春130021 [2]吉林大学第一医院神经外科,长春130021 [3]吉林大学第一医院神经内科,长春130021

出　　处：《临床神经病学杂志》2020年第2期151-153,共3页Journal of Clinical Neurology

基　　金：国家自然科学基金(81801282)。

摘　　要：细胞焦亡是新近发现的细胞死亡方式,不同于凋亡及坏死,依赖天冬氨酸特异性半胱氨酸蛋白酶(caspase-1、caspase-4、caspase-5、caspase-11),促进炎性介质IL-1β和IL-18的释放,最终导致炎症反应及细胞死亡,属于细胞程序性死亡。目前证据表明细胞焦亡广泛参与多种疾病发病机制,现将细胞焦亡在癫痫领域的研究进展做一综述,以期待为癫痫的防治提供新思路。Pyroptosis is a newly discovered cell death modality,which is different from apoptosis and necrosis.It depends on caspase-1,caspase-4,caspase-5 and caspase-11 and promotes the release of inflammatory mediators,mainly IL-1βand IL-18,and finally leads to inflammatory reaction and cell death,which belongs to programmed cell death.At present,the evidence shows that pyroptosis is widely involved in the pathogenesis of many diseases.We review the research progress of pyroptosis in epilepsy in order to provide new ideas for the prevention and treatment of epilepsy.

关 键 词：细胞焦亡 癫痫 CASPASE-1 NLRP1 NLRP3 

分 类 号：R742.1[医药卫生—神经病学与精神病学]