结直肠癌肝转移与肺转移患者的临床病理特征比较  

Comparison of clinicopathological features between liver and lung metastasis in colorectal cancer

作　　者：利基林 莫坚 王敏 安慧华 唐艳萍[1] 谢明智[2] 胡榜利 李科志[1] Li Jilin;Mo Jian;Wang Min;An Huihua;Tang Yanping;Xie Mingzhi;Hu Bangli;Li Kezhi(Department of Research,Affiliated Tumor Hospital of Guangxi Medical University,Nanning 530021,Guangxi Zhuang Autono?mous Region,China;DepartmentⅠof Chemotherapy,Affiliated Tumor Hospital of Guangxi Medical University,Nanning 530021,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]广西医科大学附属肿瘤医院实验研究部,广西南宁 530021 [2]广西医科大学附属肿瘤医院化疗一区,广西南宁 530021

出　　处：《结直肠肛门外科》2020年第2期192-195,212,共5页Journal of Colorectal & Anal Surgery

基　　金：广西科技厅科技攻关项目(桂科AB19110018);广西科自然科学基金(2017GXNSFAA198155);广西医科大学大学生创新基金项目(02610219098X)。

摘　　要：目的比较结直肠癌(CRC)肝转移与肺转移患者临床病理特征的差异。方法回顾性分析本院2015年1月至2018年1月确诊为CRC合并远处转移并行手术切除的115例患者临床资料,按照转移部位不同,分为肝转移组与肺转移组,依次分析CRC患者、结肠癌患者的临床病理特征差异。结果在CRC患者中,肺转移组的老年患者比例高于肝转移组(P<0.05),两组性别、肿瘤分化程度、T分期、N分期、KRAS突变、肿瘤原发部位、CEA、CA19-9及CA153水平比较,差异均无统计学意义(均P>0.05)。在结肠癌患者中,左半结肠癌患者相比于右半结肠癌患者观察到更高的肝转移发生率(P<0.05),两组年龄、性别、肿瘤分化程度、T分期、N分期、KRAS突变、CEA、CA19-9及CA153水平比较,差异均无统计学意义(均P>0.05)。结论肺转移组的老年CRC患者比例高于肝转移组,在左半结肠癌患者中相比于右半结肠癌患者观察到更高的肝转移发生率,但样本量有限,该研究结果还需要进行一步研究支持。Objectives To compare clinicopathological features between liver and lung metastasis in patients with colorectal can?cer(CRC).Methods This was a retrospective analysis of 115 colorectal cancer patients with distant metastasis underwent sur?gery in our hospital between January 2015 and January 2018.Patients were divided into liver or lung metastasis group,and clini?copathological features were compared between these two groups among CRC or colon cancer patients in sequence.Results Among colorectal patients,the proportion of elderly patients in the lung metastasis group was higher than that in the liver metas?tasis group(P<0.05).There was no significant difference in gender,differentiation,T stage,N stage,KRAS mutation,primary tu?mor site,carcinoembryonic antigen(CEA),carbohydrate antigen(CA19-9),and CA153(P>0.05).Among colon cancer patients,a higher incidence of liver metastasis was observed in patients with left-sided colon cancer than in patients with right-sided colon cancer(P<0.05).While age,gender,differentiation,T stage,N stage,KRAS mutation,CEA,CA19-9,and CA153 did not differ between the two groups(P>0.05).Conclusion The proportion of elderly patients with colorectal cancer in the lung metastasis group was higher than that in the liver metastasis group.A higher incidence of liver metastasis was observed in patients with left-sided colon cancer than in patients with right-sided colon cancer.Due to the limited sample size,further studies are re?quired to confirm our findings.

关 键 词：结直肠癌 肝转移 肺转移 临床病理特征 

分 类 号：R735.34[医药卫生—肿瘤]