IL-2基因单核苷酸多态性与胃癌患病风险性分析  

An analysis of single nucleotide polymorphisms of IL-2 and risk for gastric cancer

作　　者：刘贤 石国友 LIU Xian;SHI Guoyou(Clinical Laboratory,Affiliated Jiangning Hospital,Nanjing Medical University,Nanjing 211100,CHINA)

机构地区：[1]南京医科大学附属江宁医院检验科,江苏211100

出　　处：《江苏医药》2020年第3期253-256,共4页Jiangsu Medical Journal

基　　金：南京市医学科技发展项目(YKK17220)。

摘　　要：目的探讨幽门螺旋杆菌(Hp)阳性患者IL-2基因单核苷酸多态性与胃癌发生的关系。方法588例Hp阳性患者中,慢性胃炎患者362例,胃癌患者102例,正常胃壁但表现出消化不良症状的患者124例。采用限制性长度多态性-聚合酶链反应对IL-2基因多态性位点rs2069763和rs2069762进行基因型分析。结果与慢性胃炎患者和消化不良患者相比,rs2069762 GG和rs2069763 TT基因型均增加胃癌的患病风险(P<0.05)。经过单倍体分析发现,rs2069762 G+rs2069763 T等位基因组合会进一步增加胃癌的患病风险(P<0.05)。结论rs2069762 GG基因型或G等位基因、rs2069763 TT基因型或T等位基因的Hp阳性患者的胃癌患病风险较高。Objective To investigate the association between single nucleotide polymorphisms of IL-2 and development of gastric cancer in the patients with positive Helicobacter pylori(Hp).Methods Of 588 patients with positive Hp,362 cases were with chronic gastritis,102 cases were with gastric cancer and 124 cases had normal stomach with dyspepsia symptoms.The genotypes of IL-2 at rs2069763 and rs2069762 sites were analyzed by restriction fragment length polymorphism-polymerase chain reaction.Results Compared with the patients with chronic gastritis or dyspepsia,the genotypes of rs2069762 GG and rs2069763 TT could significantly increase the risk for the development of gastric cancer(P<0.05).The haploid analysis showed that the allele combination of rs2069762 G+rs2069763 T could further promote the risk for the development of gastric cancer(P<0.05).Conclusion The positive Hp patients with rs2069762 GG genotype or G allele and rs2069763 TT genotype or T allele may run a higher risk for the development of gastric cancer.

关 键 词：胃癌 幽门螺旋杆菌 基因分型 

分 类 号：R735[医药卫生—肿瘤]