长链非编码RNA MALAT1与前列腺癌的关系  

Relationship between long non-coding RNA MALAT1 and prostate cancer

作　　者：张发[1] 吴长富(综述) 罗玉红 周逢海(审校) ZHANG Fa;WU Chang-fu;LUO Yu-hong;ZHOU Feng-hai(Department of Urology,Lanzhou University First Hospital/The First School of Clinical Medicine,Lanzhou University,Lanzhou,Gansu 730000,China;Department of Urologyy Gansu Provincial Hospital,Lanzhou,Gansu 730000,China)

机构地区：[1]兰州大学第一临床医学院泌尿外科,甘肃兰州730000 [2]甘肃省人民医院泌尿外科,甘肃兰州730000

出　　处：《中华男科学杂志》2020年第2期174-179,共6页National Journal of Andrology

摘　　要：前列腺癌通常是指前列腺腺泡上皮来源的恶性肿瘤,已成为威胁老年男性健康的全球性“杀手”.前列腺癌的进展机制以及治疗策略一直是研究的重点,近年来,长链非编码RNA似乎在这当中发挥重要的作用.长链非编码RNA MALAT1在前列腺癌进展、治疗中发挥关键的作用,其不仅影响前列腺癌生物学特性,在肿瘤转移、侵袭、细胞增殖等方面都起到关键的作用,而且在肿瘤药物治疗中起到调节作用,其作用机制与ceRNA、AR信号通路等有关.本文就长链非编码RNA MALAT1与前列腺癌的关系作一综述,希望能为前列腺癌的诊治提供新的研究方向.Prostate cancer(PCa),as a malignant tumor originating in the prostate glandular epithelium,has become a global"killer"that threatens the health of elderly men.PCa-related studies have been focusing on the progression mechanisms and treatment strategies of the malignancy,particularly on the role of long non-coding RNA(lncRNA)in recent years.The lncRNA metastasis-associated lung adenocarcinoma transcript 1(MALAT1)plays a key role in the progression and treatment of PCa,as well as in its metastasis and invasion and cell proliferation.lncRNA MALAT1 not only influences the biological characteristics of PCa,but also has a regulatory effect on the medicinal treatment of the disease,its action mechanisms involving ceRNA and AR signaling pathways.This review focuses on the relationship between lncRNA MALAT1 and PCa,aiming to provide a new research direction for the diagnosis and treatment of the malignancy.

关 键 词：长链非编码RNA 转移相关的肺腺癌转录物1 前列腺癌 化疗 骨转移 

分 类 号：R737.25[医药卫生—肿瘤]