^18F-FDG PET/CT显像SUVmax预测非霍奇金淋巴瘤化疗疗效的价值  

Implication of the SUVmax of^18F-FDG PET/CT images in predicting the therapeutic effects of non-Hodgkin’s lymphoma

作　　者：赵晓佳[1] 宿伟鹏[2] 李肖红[1] 秦永德[1] ZHAO Xiaojia;SU Weipeng;LI Xiaohong;QIN Yongde(Department of Nuclear Medicine,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China;Department of Oncology,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)

机构地区：[1]新疆医科大学第一附属医院核医学科,乌鲁木齐830054 [2]新疆医科大学第一附属医院肿瘤一科,乌鲁木齐830054

出　　处：《中国癌症防治杂志》2020年第2期227-231,共5页CHINESE JOURNAL OF ONCOLOGY PREVENTION AND TREATMENT

摘　　要：目的探讨非霍奇金淋巴瘤(non-Hodgkin’s lymphoma,NHL)患者治疗前^18F-FDG PET/CT显像中最大标准化摄取值(SUVmax)与疗效的关系。方法回顾性分析2017年7月-2019年3月在我科行^18F-FDG PET/CT显像并经淋巴结活检确诊为NHL的146例患者的资料。根据国际工作组织淋巴瘤疗效评估标准(IWC)将化疗6个疗程的NHL患者分为有效组和无效组。分析SUVmax与临床病理特征及疗效的关系。结果在NHL患者中,临床分期、恶性程度、病灶大小、坏死情况、骨髓浸润、治疗前血清乳酸脱氢酶、Ki-67阳性率与SUVmax有关(P<0.05);无效组治疗前SUVmax高于有效组(16.68±6.16 vs 12.16±5.27,t=4.654,P=0.001);治疗前SUVmax评估NHL患者疗效的最佳截断值为14.836,对应的AUC为0.835(95%CI:0.751~0.920),特异度为80.0%,敏感度为77.4%;治疗前SUVmax>14.836是影响NHL患者疗效的独立危险因素(OR=1.688,95%CI:1.179~2.4^18,P=0.007)。结论^18F-FDG PET/CT显像中的SUVmax可评估NHL患者的化疗疗效。Objective To explore the relationship between the maximum standard uptake value(SUVmax)of^18F-FDG PET/CT images and the therapeutic effects in patients with non-Hodgkin’s lymphoma(NHL)before treatment.Methods The clinical data of 146 patients diagnosed with NHL by lymph node biopsy on^18F-FDG PET/CT images in our department from July 2017 to March 2019 were analyzed retrospectively.According to the International Working Organization Evaluation Standard for Lymphoma Efficacy(IWC),NHL patients with 6 courses of chemotherapy were divided into effective and ineffective groups to analyze the relationship between SUVmax and clini-copathological characteristics and curative effect.Results The clinical stage,malignancy,lesion size,necrosis,bone marrow infiltration,serum lactae dehydrogenase before treatment,Ki-67 positive rate in NHL patients were related to the SUVmax(P<0.05).The SUVmax before treatment of the ineffective group was higher than that of the effective group(16.68±6.16 vs 12.16±5.27,t=4.654,P=0.001).The optimal cut-off value of SUVmax to evaluate the efficacy of N HL patients before treatment was 14.836,the corresponding AUC was0.835(95%CI:0.751-0.920),and the specificity was 80.0%,sensitivity was 77.4%.SUVmax>14.836 before treatment was an independent risk factor affecting the efficacy of NHL patients(OR=1.688,95%CI:1.179-2.4^18,P=0.007).Conclusion The SUVmax in^18F-FDG PET/CT images can be used to evaluate the efficacy of NHL patients.

关 键 词：非霍奇金淋巴瘤 ^18F-脱氧葡萄糖PET-CT显像 最大标准化摄取值 疗效 

分 类 号：R733.1[医药卫生—肿瘤]