SLC1A1基因多态性与中国汉族人群强迫症的相关性  

Association between SLC1A1 gene polymorphism and obsessive-compulsive disorder in Chinese Han population

作　　者：任建娟[1] 唐牟尼 陈晓莹[3] 傅正闯 REN Jianjuan;TANG Mouni;CHEN Xiaoying;FU Zhengchuang(Mental Health Center,Zhejiang Xiaoshan Hospital,Hangzhou 311200,China;Department of Geriatric,Guangzhou Huiai Hosptial,Guangzhou 510370,China;Department of Psychology,Huizhou Municipal Central Hospital,Huizhou 516008,China)

机构地区：[1]浙江萧山医院精神卫生中心,浙江杭州311200 [2]广州市惠爱医院老年科,广东广州510370 [3]惠州市中心人民医院心理精神科,广东惠州516008

出　　处：《温州医科大学学报》2020年第3期237-240,共4页Journal of Wenzhou Medical University

基　　金：杭州市科技计划项目(20181228Y88)。

摘　　要：目的:探讨谷氨酸转运体基因(SLC1A1)与中国汉族人群强迫症(OCD)的关系。方法:采用病例对照研究,以125例患者(OCD组)和125例正常人(对照组)作为研究对象,检测SLC1A1基因的3个位点(rs301430、rs301434、rs301979),分析这些位点等位基因、基因型分布,以及单倍体与OCD之间的关系。结果:3个位点的等位基因和基因型频率分布在OCD组和对照组中的差异无统计学意义(P>0.05)。经性别分层分析,相较于对照组,女性患者rs301979位点等位基因和基因型频率分布与对照组差异有统计学意义(χ^2=7.875,P=0.019;χ^2=7.331,P=0.007),而男性患者中所有位点的等位基因和基因型频率分布差异均无统计学意义(P>0.05)。三位点单倍体T-A-G在2组中的差异有统计学意义(χ^2=6.206,P=0.013)。结论:SLC1A1基因rs301979位点可能是女性OCD的易感基因位点,rs301430、rs301434、rs301979的单倍体T-A-G可能与中国汉族人群OCD发病相关。Objective:To investigate the relationship between solute carrier family 1 member 1 gene(SLC1A1)and obsessive-compulsive disorder(OCD)in Chinese Han population.Methods:A case-control study was conducted on 125 patients(OCD group)and 125 normal people(control group)to detect 3 loci of SLC1A1 gene(rs301430,rs301434,rs301979).The allele and genotype distribution of these loci and the relationship between haploid and OCD were analyzed.Results:There was no significant difference in allele and genotype frequency distribution of 3 loci between OCD group and control group(P>0.05).Gender stratified analysis showed that the frequency distribution of allele and genotype of rs301979 site in female patients was significantly different from that in the control group(χ^2=7.875,P=0.019;χ^2=7.331,P=0.007),while the distribution of allele and genotype frequency of all loci in male patients was not statistically significant(P>0.05).The difference between haploid T-A-G of 3-loci in the 2 groups was statistically significant(χ^2=6.206,P=0.013).Conclusion:The rs301979 site of SLC1A1 gene may be the susceptibility gene site of female OCD,and the haploid T-A-G of rs301430,rs301434 and rs301979 may be related to the incidence of OCD in Chinese Han population.

关 键 词：强迫性障碍 谷氨酸转运体基因 多态性 易感基因 

分 类 号：R749.7[医药卫生—神经病学与精神病学] R394.3[医药卫生—临床医学]