骨髓间充质干细胞在肿瘤发生及治疗作用中的研究进展  

Research Progress of Bone Marrow Mesenchymal Stem Cells in Tumorigenesis and Therapeutic Effects

作　　者：胡星遥 孙慧娟 朱静 张洁 尚广彬 HU Xing-yao;SUN Hui-juan;ZHU Jing;ZHANG Jie;SHANG Guang-bin(Jiangxi University of Traditional Chinese Medicine,Jiangxi Provincial Key Laboratory of Biology of Traditional Chinese Medicine,Nanchang 330004,Jiangxi,China)

机构地区：[1]江西中医药大学江西省中医病因生物学重点实验室,中国江西南昌330004

出　　处：《生命科学研究》2020年第2期147-152,167,共7页Life Science Research

基　　金：国家自然科学基金资助项目(81260653);江西中医药大学资助项目(2014ZR021)。

摘　　要：骨髓间充质干细胞(bone marrow mesenchymal stemcells,BMSCs)主要存在于骨髓中,具有多向分化和增殖的能力。BMSCs与肿瘤关系密切,除了对肿瘤具有趋向性,还可以影响肿瘤细胞的生长增殖、侵袭转移和血管生成等,在肿瘤的发生、发展过程中具有重要调节作用。同时BMSCs在肿瘤基因治疗和免疫治疗中的应用也日趋受到重视,为肿瘤治疗拓展了研究思路。本文主要就BMSCs对肿瘤发生、发展的影响,及其在肿瘤治疗中的应用进行综述。Bone marrow mesenchymal stemcells(BMSCs)are mainly found in the bone marrow and have multidifferentiation and proliferation potential.They closely correlate with tumors.In addition to their tumor tropism,they can also affect tumor cell growth and proliferation,migration and metastasis,and angiogenesis.They play an important role in the regulation and development of tumors.At the same time,more and more attention has been paid to the application of BMSCs in tumor gene therapy and immunotherapy,providing novel ideas for cancer therapy.Herein,effects of BMSCs on tumorigenesis and development,as well as their applications in tumor therapy,are reviewed.

关 键 词：骨髓间充质干细胞(BMSCs) 肿瘤趋向性 肿瘤微环境 肿瘤基因治疗 肿瘤免疫治疗 

分 类 号：Q25[生物学—细胞生物学] R730.1[医药卫生—肿瘤]