阿托伐他汀联合雄激素阻断治疗对晚期前列腺癌PSA、VEGF、MMP-9及血脂水平的影响  

Effect of atorvastatin combined with androgen blockade on PSA,VEGF,MMP-9 and serum lipid levels in advanced prostate cancer

作　　者：王叶萍 吴永[2] 张小明 WANG Ye-ping;WU Yong;ZHANG Xiao-ming(Clinical Laboratory,Shengzhou Hospital of Traditional Chinese Medicine,Shenzhou 312400,Zhejiang,China;不详)

机构地区：[1]嵊州市中医院检验科,浙江嵊州312400 [2]嵊州市中医院外科,浙江嵊州312400

出　　处：《广东医学》2020年第6期622-627,共6页Guangdong Medical Journal

摘　　要：目的探讨阿托伐他汀联合雄激素阻断治疗对晚期前列腺癌患者的前列腺特异性抗原(PSA)、血管内皮生长因子(VEGF)、基质金属蛋白酶-9(MMP-9)及血脂水平的影响。方法选择前列腺癌晚期患者94例,按照随机数字表法分为对照组(n=47)和观察组(n=47)。对照组患者给予雄性激素阻断治疗,观察组患者在对照组基础上给予阿托伐他汀治疗。比较两组的治疗效果、治疗前后的血清PSA、VEGF、MMP-9水平、血脂水平以及在治疗过程中的不良反应出现情况。结果观察组患者的治疗效果、治疗有效率和疾病控制率均优于对照组,差异有统计学意义(P<0.05)。经过治疗后,两组的PSA、VEGF、MMP-9均降低(P<0.05),观察组的PSA、VEGF、MMP-9均低于对照组(P<0.05)。两组的总胆固醇和三酰甘油均降低(P<0.05),观察组的总胆固醇和三酰甘油均低于对照组(P<0.05),两组的各类不良反应数据差异均无统计学意义(P>0.05)。结论使用阿托伐他汀联合雄激素阻断治疗干预晚期前列腺癌症患者,可以明显改善PSA、VEGF、MMP-9及血脂的水平,提升治疗效果,安全性良好。Objective To investigate the effects of atorvastatin combined with androgen blockade on prostate specific antigen(PSA),vascular endothelial growth factor(VEGF),matrix metalloproteinase-9(MMP-9)and serum lipid levels in patients with advanced prostate cancer.Methods Ninty-four patients with advanced prostate cancer were enrolled.According to the random number table method,they were divided into control group(n=47)and observation group(n=47).Patients in the control group were treated with androgen blockade,and patients in the observation group were given with atorvastatin on the basis of the control group.The therapeutic effects of the two groups were compared.The levels of serum PSA,VEGF and MMP-9 before and after treatment were compared.The blood lipid levels before and after treatment were compared.The adverse reactions of the two groups during the treatment were compared,so was the treatment satisfaction.Results The therapeutic effect,treatment efficiency and disease control rate of the observation group were significantly better than the control group(P<0.05).After treatment,PSA,VEGF and MMP-9 were significantly reduced in both groups(P<0.05).After treatment,the PSA,VEGF and MMP-9 in the observation group were significantly lower than those in the control group(P<0.05).After treatment,total cholesterol and triglycerides were significantly reduced in both groups(P<0.05).After treatment,the total cholesterol and triglyceride in the observation group were significantly lower than those in the control group(P<0.05).There were no significant differences in adverse reactions between the two groups(P>0.05).Conclusion The use of atorvastatin combined with androgen blockade in patients with advanced prostate cancer can significantly improve the levels of PSA,VEGF,MMP-9 and blood lipids,improve the treatment effect,and have good safety.

关 键 词：阿托伐他汀 雄激素 前列腺癌 血脂 胆固醇 

分 类 号：R737.25[医药卫生—肿瘤] R96[医药卫生—临床医学]