宫颈癌前病变高危型HPV检测与宫颈液基细胞早期筛查的临床分析  

Clinical Analysis of High-risk HPV Detection and Early Screening of Cervical Fluid-based Cells for Precancerous Lesions

作　　者：孟彬 MENG Bin(Qingdao City Shibei District Maternal and Child Health Family Planning Service Center,Qingdao 266033,China)

机构地区：[1]青岛市市北区妇幼保健计划生育服务中心,山东青岛266033

出　　处：《中国医药指南》2020年第12期115-116,共2页Guide of China Medicine

摘　　要：目的分析宫颈癌前病变采用高危型HPV检测和宫颈液基细胞早期筛查的临床效果。方法选择2016年11月至2019年11月在本中心接受体检1000例患者为研究对象。所有患者均接受高危型HPV检测和宫颈液基细胞学检查,宫颈液基细胞学异常(ASC-US及以上)和(或)高危型HPV结果阳性者均接受病理学检查,并以病理学检查结果为基准,对比分析高危型HPV检测与宫颈液基细胞学检查的灵敏度、特异性以及准确率差异。结果1000例体检患者接受高危型HPV检测以及宫颈液基细胞学检查后,高危型HPV诊断阴性820例,阳性180例,宫颈液基细胞检查阴性816例,异常184例,所有宫颈液基细胞学异常(ASC-US及以上)和(或)高危型HPV结果阳性者,均接受病理学检查,208例患者确诊为宫颈癌前病变(CINⅠ~CINⅢ),其中180例高危型HPV阳性患者中,确诊宫颈癌早期病变130例,阳性率13.0%,184例宫颈液基细胞学检查异常患者中,确诊宫颈癌早期病变163例,阳性率16.3%,高危型HPV检测与宫颈液基细胞学检查比较,特异性与准确率对比差异无统计学含义(P>0.05),而灵敏度对比差异具有统计学含义(P<0.05)。结论采用高危型HPV检测和宫颈液基细胞学检查进行宫颈癌的早期筛查,可了解患者高危型HPV感染情况和宫颈癌前病变及宫颈癌的发病趋势,宫颈液基细胞学检查在宫颈癌前病变的早期诊断中灵敏度更高,便于及早介入治疗,有效改善其预后,降低宫颈癌的发生,具有临床意义。Objective To analyze the clinical effect of high-risk HPV detection and early screening of cervical fluid-based cells in cervical precancerous lesions.Methods 1000 patients were selected for medical examination in this center from November 2016 to November 2019.All the patients received high-risk HPV test and cervical fluid-based cytology.All patients with abnormal cervical fluid-based cytology(ASC-US and above)and/or high-risk HPV were tested pathologically.The sensitivity and specificity of high-risk HPV test and cervical fluid-based cytology were compared and analyzed based on the results of pathology Sex and accuracy differences.Results After 1000 cases of high-risk HPV test and cervical fluid-based cytology,820 cases of high-risk HPV were negative,180 cases were positive,816 cases were negative for cervical fluid-based cells,184 cases were abnormal,130 cases were diagnosed in 180 cases of high-risk HPV positive patients,including 130 cases of early-stage cervical cancer.The positive rate was 13.0%,among 184 patients with abnormal cervical fluid-based cytology,163 were diagnosed with early lesions of cervical cancer,with a positive rate of 16.3%.There was no significant difference in specificity and accuracy between high-risk HPV and cervical fluid-based cytology(P>0.05),but the difference in sensitivity was statistically significant(P<0.05).Conclusion Using high-risk HPV test and cervical fluid-based cytology for early screening of cervical cancer can understand the high-risk HPV infection and the trend of cervical precancerous lesions and cervical cancer.The early diagnosis of precancerous lesions with higher sensitivity,convenient early interventional treatment,effectively improve its prognosis and reduce the occurrence of cervical cancer,has clinical significance.

关 键 词：宫颈癌 宫颈液基细胞 早期筛查 高危型HPV 

分 类 号：R737.33[医药卫生—肿瘤]