髓样细胞触发受体2对阿尔茨海默病的诊断意义  

Significance of triggering receptor expresses on myeloid cells-2 in the diagnosis of Alzheimer’s disease

作　　者：陈建玲[1] 李婷 向伟[1] 钱时兴[1] 陆光华[1] 胡卫红[1] CHEN Jianling;LI Ting;XIANG Wei(The Second Department of Geriatrics,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心老年二科,上海200030 [2]长宁区精神卫生中心老年科,上海200335

出　　处：《中风与神经疾病杂志》2020年第4期310-313,共4页Journal of Apoplexy and Nervous Diseases

基　　金：长宁区精神卫生中心院级课题(No.2017001);长宁区科委一般项目(No.CNKW2018Y24)。

摘　　要：目的探讨髓样细胞触发受体2(TREM2)的表达水平对阿尔茨海默病痴呆的诊断意义。方法选取60例阿尔茨海默病(AD)患者作为研究组,20例健康体检者作为对照组。用酶联免疫吸附(ELISA)法测定血清中TREM2、C反应蛋白(CRP)和白细胞介素6(IL-6)的含量。比较两组TREM2、CRP和IL-6的表达差异及相关性。在简易精神状态检查量表(MMSE)、缺血指数量表(HIS)、汉密尔顿抑郁量表(HAMD)、CDR量表的基础上,用蒙特利尔认知评估量表(MoCA)作为主要认知评估工具,比较TREM2与MMSE和MoCA量表评分的相关性。通过受试者工作特征曲线(ROC)和曲线下面积(AUC)来判断TREM2在AD诊断中的应用价值。结果AD患者血清中TREM2水平显著升高(P<0.05)。TREM2水平与MMSE和MoCA评分之间发生了负相关(均P<0.01)。AD患者的IL-6和CRP水平升高(均P<0.05)。TREM2水平与血清IL-6和CRP呈正相关(均P<0.05)。结论TREM2在AD患者外周血中表达增高,与认知功能相关,可能是诊断AD的有前途的生物标志物。Objective To investigate the significance of triggering receptor expresses on myeloid cells-2(TREM2)in the diagnosis of Alzheimer’s disease(AD).Methods Sixty patients with AD were selected as the study group,meanwhile,twenty healthy subjects were selected as the control group.The levels of TREM2,C-reactive protein(CRP)and interleukin 6(IL-6)in serum were determined by enzyme-linked immunosorbent assay(ELISA).The differences and the correlation between TREM2 and CRP and IL-6 levels were compared between the two groups.On the basis of Mini-mental State Examination(MMSE),Hachinski Inchemic Score(HIS),Hamilton Depression Scale(HAMD)and Clinical Dementia Rating(CDR),the Montreal Cognitive Assessment Scale(MoCA)was used as the main cognitive assessment tool to compare the correlation between TREM2,MMSE and MoCA.The application value of TREM2 in the diagnosis of AD was judged by the receiver working characteristic curve(ROC)and the area under the curve(AUC).Results The level of TREM2 in serum of patients with AD was significantly higher than that of control group(P<005).There was a negative correlation between the level of TREM2 and the scores of MMSE and MoCA(P<001).The levels of IL-6 and CRP in patients with AD were significantly higher than those in control group(P<005).The level of TREM2 was positively correlated with serum IL-6 and CRP(P<005).Conclusion The expression of TREM2 in peripheral blood of patients with AD is increased,which is related to cognitive function,and may be a promising biomarker for the diagnosis of AD.

关 键 词：髓样细胞触发受体2 阿尔茨海默病 认知功能 蒙特利尔认知评估量表 生物标志物 

分 类 号：R749.1[医药卫生—神经病学与精神病学]